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1. (WO2010115989) DIAGNOSTIC MYCOBACTERIUM TUBERCULOSIS TEST

Pub. No.:    WO/2010/115989    International Application No.:    PCT/EP2010/054721
Publication Date: Fri Oct 15 01:59:59 CEST 2010 International Filing Date: Sat Apr 10 01:59:59 CEST 2010
IPC: G01N 33/569
G01N 33/50
C07K 14/00
A61K 39/00
Applicants: LALVANI, Ajit
Inventors: LALVANI, Ajit
Title: DIAGNOSTIC MYCOBACTERIUM TUBERCULOSIS TEST
Abstract:
A method of diagnosing Mycobacterium tuberculosis infection in a human, or of determining whether a human has been exposed to Mycobacterium tuberculosis, comprising (i) contacting T-cells from said human with one or more of (a) a peptide having the sequence shown in SEQ ID NO 20, (b) a peptide having or comprising the sequence of at least 8 consecutive amino acids of the sequence shown in SEQ. ID NO 20; or (c) a peptide having or comprising a sequence which is capable of binding to a T-cell receptor which recognises a peptide as defined in (a) or (b); and (ii) determining whether any of the said T-cells recognise said peptide, wherein steps (i) and (ii) are optionally carried out in vitro. The peptide is the product of the RV3615c gene.