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Pub. No.:    WO/2010/115843    International Application No.:    PCT/EP2010/054418
Publication Date: 14.10.2010 International Filing Date: 01.04.2010
A61K 39/00 (2006.01), C07K 14/47 (2006.01), C07K 16/18 (2006.01), G01N 33/53 (2006.01)
Applicants: AC Immune S.A. [--/CH]; EPFL-PSE Building B CH-1015 Lausanne (CH) (For All Designated States Except US).
K. U. Leuven Research & Development [BE/BE]; Minderbroederstraat 8A Box 5051 B-3000 Leuven (BE) (For All Designated States Except US).
PFEIFER, Andrea [DE/CH]; (CH) (For US Only).
MUHS, Andreas [DE/CH]; (CH) (For US Only).
VAN LEUVEN, Fred [BE/BE]; (BE) (For US Only).
PIHLGREN, Maria [SE/CH]; (CH) (For US Only)
Inventors: PFEIFER, Andrea; (CH).
MUHS, Andreas; (CH).
Agent: VOSSIUS & PARTNER; Basel Office - No. 31 Siebertstraße 4 81675 München (DE)
Priority Data:
09157303.0 03.04.2009 EP
Abstract: front page image
(EN)The present invention is related to methods and pharmaceutical compositions for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with neurofibrillary tangles. In particular, the invention relates to pharmaceutical composition comprising an antigenic peptide, particularly an antigenic phospho-peptide mimicking a major pathological phospho-epitope of protein tau, for the therapeutic and diagnostic use in the treatment of tauopathies including Alzheimer's Disease.
(FR)La présente invention concerne des procédés et des compositions pharmaceutiques destinées à une utilisation thérapeutique et diagnostique dans le traitement de maladies et troubles qui sont provoqués par une dégénérescence fibrillaire ou qui lui sont associés. L'invention concerne en particulier une composition pharmaceutique comprenant un peptide antigénique, particulièrement un phosphopeptide antigénique imitant un phospho-épitope pathologique majeur de la protéine tau, destinée à une utilisation thérapeutique et diagnostique dans le traitement de tauopathies comprenant la maladie d'Alzheimer.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)