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1. (WO2010115841) METHODS AND MEANS FOR TREATMENT OF OSTEOARTHRITIS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2010/115841 International Application No.: PCT/EP2010/054412
Publication Date: 14.10.2010 International Filing Date: 01.04.2010
IPC:
G01N 33/50 (2006.01)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
Applicants: BRYS, Reginald Christophe Xavier[BE/BE]; BE (UsOnly)
NELLES, Luc[BE/BE]; BE (UsOnly)
VANDEGHINSTE, Nick Ernest Rene[BE/BE]; BE (UsOnly)
MILLE-BAKER, Blandine[FR/NL]; NL (UsOnly)
TESSARI, Michela Angela[IT/NL]; NL (UsOnly)
Galapagos NV[BE/BE]; Generaal De Wittelaan L11/A3 B-2800 Mechelen, BE (AllExceptUS)
Inventors: BRYS, Reginald Christophe Xavier; BE
NELLES, Luc; BE
VANDEGHINSTE, Nick Ernest Rene; BE
MILLE-BAKER, Blandine; NL
TESSARI, Michela Angela; NL
Agent: TEUTEN, Andrew; Sagittarius IP Taylor House 39 High Street Marlow Buckinghamshire SL7 1AF, GB
Priority Data:
61/211,74001.04.2009US
Title (EN) METHODS AND MEANS FOR TREATMENT OF OSTEOARTHRITIS
(FR) PROCÉDÉS ET MOYENS DE TRAITEMENT DE L'ARTHRITE
Abstract:
(EN) The invention relates to the field of medicinal research, cartilage physiology and diseases involving the degeneration of cartilage tissue. More specifically, the invention relates to methods and means for identifying compounds that inhibit catabolic processes in chondrocytes and that decrease the degradation of cartilage and/or ECM. The invention also relates to the compounds that are useful in the treatment of osteoarthritis. The invention also relates to targets, the modulation of which results in a decrease in the degradation of ECM and/or cartilage and decrease inflammation. In addition, the invention relates to compositions and methods for the use thereof in treating conditions that are characterized by the degradation of ECM and/or cartilage and inflammation.
(FR) La présente invention concerne le domaine de la recherche médicale, de la physiologie des cartilages et des maladies impliquant la dégénérescence du tissu cartilagineux. Plus spécifiquement, l'invention concerne des procédés et des moyens permettant d'identifier des composés qui inhibent les processus cataboliques dans les chondrocytes et qui diminuent la dégradation du cartilage et/ou de la matrice extracellulaire (ECM). L'invention concerne également les composés qui sont utiles dans le traitement de l'arthrose. L'invention concerne également des cibles dont la modulation aboutit à une diminution de la dégradation de l'ECM et/ou du cartilage et à une diminution de l'inflammation. De plus, l'invention concerne des compositions et des procédés destinés à être utilisés dans le traitement de troubles qui sont caractérisés par la dégradation de l'ECM et/ou du cartilage et par une inflammation.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)