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1. (WO2010115825) MODULATION OF ADIPOSE TRIGLYCERIDE LIPASE FOR PREVENTION AND TREATMENT OF CACHEXIA, LOSS OF WEIGHT AND MUSCLE ATROPHY AND METHODS OF SCREENING THEREFOR
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2010/115825 International Application No.: PCT/EP2010/054363
Publication Date: 14.10.2010 International Filing Date: 31.03.2010
IPC:
G01N 33/50 (2006.01) ,C12Q 1/44 (2006.01) ,A61K 31/00 (2006.01)
Applicants: ZIMMERMANN, Robert[AT/AT]; AT
ZECHNER, Rudolf[AT/AT]; AT
HAEMMERLE, Günther[AT/AT]; AT
HÖFLER, Gerald[AT/AT]; AT
DAS, Suman[IN/AT]; AT
LASS, Achim[AT/AT]; AT
Inventors: ZIMMERMANN, Robert; AT
ZECHNER, Rudolf; AT
HAEMMERLE, Günther; AT
HÖFLER, Gerald; AT
DAS, Suman; AT
LASS, Achim; AT
Agent: MEIER, Jürgen; Vossius & Partner Siebertstraße 4 81675 München, DE
Priority Data:
61/211,60431.03.2009US
Title (EN) MODULATION OF ADIPOSE TRIGLYCERIDE LIPASE FOR PREVENTION AND TREATMENT OF CACHEXIA, LOSS OF WEIGHT AND MUSCLE ATROPHY AND METHODS OF SCREENING THEREFOR
(FR) MODULATION DE L'ADIPOSE TRIGLYCÉRIDE LIPASE POUR PRÉVENIR ET TRAITER LA CACHEXIE, LA PERTE DE POIDS ET L'ATROPHIE MUSCULAIRE ET PROCÉDÉS DE CRIBLAGE À DES FINS D'IDENTIFICATION
Abstract:
(EN) The present invention relates to agents, and methods for identifying compounds, which agents and compounds are effective in the treatment, and more particularly, that inhibit cachexia, and its associated or related disorders and conditions. In addition, the invention relates to compositions and methods for the use thereof in treating conditions that are characterized by cachexia, and its associated or related disorders and conditions and/or cachexia, and its associated or related disorders and conditions, such as for example, cancer cachexia and cachexia associated with AIDS, autoimmune disorders, drug addiction, alcoholism, chronic inflammatory disorders, cirrhosis of the liver, anorexia and neurodegenerative disease. In particular, the diagnostic marker and drug target of the invention is the ATGL Lipase, which can be inhibited by e.g. siRNAs and compounds with any of the following structures (I).
(FR) Cette invention concerne des agents et des procédés permettant d'identifier des composés, lesdits agents et composés étant efficaces pour traiter, et plus particulièrement, pour inhiber la cachexie, et les troubles et affections qui lui sont associés ou apparentés. De plus, l'invention concerne des compositions et des procédés pour les utiliser dans le traitement d'affections qui sont caractérisées par la cachexie, et les troubles et affections qui lui sont associés ou apparentés et/ou la cachexie, et les troubles et affections qui lui sont associés ou apparentés, tels que, par exemple, la cachexie cancéreuse, et la cachexie associée au SIDA, les troubles auto-immuns, la toxicomanie, l'alcoolisme, les troubles inflammatoires chroniques, la cirrhose du foie, l'anorexie et les maladies neurodégénératives.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)