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Machine translation
1. (WO2010115491) PIPERIDINE AND PIPERAZINE DERIVATIVES AS AUTOTAXIN INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2010/115491 International Application No.: PCT/EP2010/001323
Publication Date: 14.10.2010 International Filing Date: 03.03.2010
IPC:
C07D 211/30 (2006.01) ,C07D 401/06 (2006.01) ,C07D 401/12 (2006.01) ,C07D 401/14 (2006.01) ,C07D 405/06 (2006.01) ,C07D 405/14 (2006.01) ,C07D 413/14 (2006.01) ,C07D 417/14 (2006.01) ,C07D 471/10 (2006.01) ,A61K 31/4427 (2006.01) ,A61K 31/4523 (2006.01)
Applicants: SCHIEMANN, Kai[DE/DE]; DE (UsOnly)
SCHULTZ, Melanie[DE/DE]; DE (UsOnly)
STAEHLE, Wolfgang[DE/DE]; DE (UsOnly)
MERCK PATENT GMBH[DE/DE]; Frankfurter Strasse 250 64293 Darmstadt, DE (AllExceptUS)
Inventors: SCHIEMANN, Kai; DE
SCHULTZ, Melanie; DE
STAEHLE, Wolfgang; DE
Agent: MERCK PATENT GMBH; Frankfurter Strasse 250 64293 Darmstadt, DE
Priority Data:
09 004 856.2 02.04.2009EP
Title (EN) PIPERIDINE AND PIPERAZINE DERIVATIVES AS AUTOTAXIN INHIBITORS
(FR) DÉRIVÉS DE PIPÉRIDINE ET DE PYRAZINE COMME INHIBITEURS DE L'AUTOTAXINE
Abstract: front page image
(EN) The present invention relates to piperidine and pyrazine derivatives according to formulae (Ia), (Ib) and (II) as autotaxin inhibitors and the use of such compounds for the treatment and/or prophylaxis of physiological and/or pathophysiological conditions, which are caused, mediated and/or propagated by increased lysophosphatic acid levels and/or the activation of autotaxin, in particular of different cancers.
(FR) La présente invention concerne des dérivés de pipéridine et de pyrazine de formules (Ia), (Ib) et (II) comme inhibiteurs de l'autotaxine et l'utilisation de tels composés pour le traitement et/ou la prophylaxie de troubles physiologiques et/ou pathophysiologiques qui sont provoqués, médiés et/ou propagés par une augmentation du taux d'acide lysophosphatique et/ou l'activation de l'autotaxine, en particulier de différents cancers.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)