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1. (WO2010115278) METHODS AND COMPOSITIONS FOR TREATING AND PREVENTING SHIGA TOXIN-PRODUCING ESCHERICHIA COLI INFECTION
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2010/115278 International Application No.: PCT/CA2010/000516
Publication Date: 14.10.2010 International Filing Date: 06.04.2010
IPC:
C07K 19/00 (2006.01) ,A61K 39/108 (2006.01) ,A61K 39/385 (2006.01) ,A61P 31/04 (2006.01) ,A61P 37/04 (2006.01) ,C07K 14/245 (2006.01)
Applicants: POTTER, Andrew, A.[CA/CA]; CA (UsOnly)
ASPER, David[CA/CA]; CA (UsOnly)
ROGAN, Dragan[CA/CA]; CA (UsOnly)
UNIVERSITY OF SASKATCHEWAN[CA/CA]; 120 Veterinary Road Saskatoon, Saskatchewan S7N 5E3, CA (AllExceptUS)
BIONICHE LIFE SCIENCES INC.[CA/CA]; 231 Dundas Street East Belleville, Ontario K8N 1E2, CA (AllExceptUS)
Inventors: POTTER, Andrew, A.; CA
ASPER, David; CA
ROGAN, Dragan; CA
Agent: ERRAT, Judy; Gowling Lafleur Henderson LLP 160 Elgin Street, Suite 2600 Ottawa, Ontario K1P 1C3, CA
Priority Data:
61/211,98906.04.2009US
61/216,60819.05.2009US
Title (EN) METHODS AND COMPOSITIONS FOR TREATING AND PREVENTING SHIGA TOXIN-PRODUCING ESCHERICHIA COLI INFECTION
(FR) PROCÉDÉS ET COMPOSITIONS POUR TRAITER ET PRÉVENIR UNE INFECTION À ESCHERICHIA COLI PRODUISANT LA TOXINE SHIGA
Abstract:
(EN) Compositions and methods for stimulating an immune response against Shiga toxin-producing Escherichia coli (STEC) antigens are disclosed. The compositions include a multiple epitope fusion protein comprising more than one epitope of an immunogenic STEC protein from more than one STEC serotype. Additional compositions include at least two purified STEC proteins, wherein the STEC proteins are selected from a full-length STEC protein, an immunogenic fragment or variant thereof, wherein at least one of the STEC proteins generates antibodies that react with STEC 0157 and at least one other STEC serotype.
(FR) L'invention concerne des compositions et des procédés de stimulation d'une réponse immunitaire contre des antigènes d'Escherichia coli (STEC) produisant la toxine Shiga. Les compositions comprennent une protéine de fusion à épitopes multiples comprenant plus d'un épitope d'une protéine de STEC immunogène de plusieurs sérotypes STEC. D'autres compositions comprennent au moins deux protéines STEC purifiées, les protéines STEC étant choisies parmi une protéine STEC complète, un fragment immunogène ou une variante de celle-ci, au moins l'une des protéines STEC générant des anticorps qui réagissent avec STEC 0157 et au moins un autre sérotype de STEC.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)