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1. (WO2010115127) USE OF ID4 FOR DIAGNOSIS AND TREATMENT OF CANCER
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2010/115127 International Application No.: PCT/US2010/029814
Publication Date: 07.10.2010 International Filing Date: 02.04.2010
IPC:
C12Q 1/68 (2006.01) ,G01N 33/53 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
Applicants:
HOON, Dave, S.,B. [US/US]; US (UsOnly)
UMETANI, Naoyuki [JP/JP]; JP (UsOnly)
JOHN WAYNE CANCER INSTITUTE [US/US]; St. John South Health Center 2200 Santa Monica Boulevard Santa Monica, CA 90404, US (AllExceptUS)
Inventors:
HOON, Dave, S.,B.; US
UMETANI, Naoyuki; JP
Agent:
DUEPPEN, Lara, J.; Perkins Coie LLP Patent - LA P.O. Box 1208 Seattle, WA 98111-1208, US
Priority Data:
12/417,57702.04.2009US
Title (EN) USE OF ID4 FOR DIAGNOSIS AND TREATMENT OF CANCER
(FR) UTILISATION DE ID4 POUR LE DIAGNOSTIC ET LE TRAITEMENT DU CANCER
Abstract:
(EN) The invention relates to a method of determining whether a human subject is suffering from or at risk for developing pancreatic cancer by determining the methylation level of an ID4 gene promoter or the expression level of an ID4 gene in a biological sample from a human subject. Also disclosed are a method of analyzing the methylation level of an ID4 gene promoter or the expression level of an ID4 gene in a pancreatic cancer cell, and a method of inhibiting the methylation of an ID4 gene promoter or enhancing the expression of an ID4 gene by contacting a pancreatic cancer cell with a compound that decreases the methylation level of an ID4 gene promoter or increases the expression level of an ID4 gene in the cell.
(FR) La présente invention concerne un procédé servant à déterminer si un sujet humain souffre ou risque de développer un cancer pancréatique en déterminant le taux de méthylation d'un promoteur de gène ID4 ou le taux d'expression d'un gène ID4 dans un échantillon biologique d'un sujet humain. La présente invention concerne en outre un procédé d'analyse du taux de méthylation d'un promoteur de gène ID4 ou du taux d'expression d'un gène ID4 dans une cellule de cancer pancréatique, et un procédé d'inhibition de la méthylation d'un promoteur de gène ID4 ou l'augmentation de l'expression d'un gène ID4 par mise en contact d'une cellule de cancer pancréatique avec un composé qui diminue le taux de méthylation d'un promoteur de gène ID4 ou augmente le taux d'expression d'un gène ID4 dans la cellule.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)