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1. (WO2010115124) COMPOSITIONS OF CHOLINESTERASE INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2010/115124 International Application No.: PCT/US2010/029809
Publication Date: 07.10.2010 International Filing Date: 02.04.2010
IPC:
A61K 31/221 (2006.01) ,A61P 25/28 (2006.01) ,A61P 25/00 (2006.01)
Applicants: DU, Shoucheng[CN/US]; US (UsOnly)
ANDERSEN, Marc, W.[US/US]; US (UsOnly)
COUGHLIN, Daniel[US/US]; US (UsOnly)
KOLCHINSKI, Alexander[US/US]; US (UsOnly)
COLUCID PHARMACEUTICALS, INC.; 2530 Meridian Parkway Suite 300 Durham, NC 27713, US (AllExceptUS)
Inventors: DU, Shoucheng; US
ANDERSEN, Marc, W.; US
COUGHLIN, Daniel; US
KOLCHINSKI, Alexander; US
Agent: ELRIFI, Ivor, R.; Mintz Levin Cohn Ferris Glovsky And Popeo, P.C. One Financial Center Boston, MA 02111, US
Priority Data:
61/166,14302.04.2009US
Title (EN) COMPOSITIONS OF CHOLINESTERASE INHIBITORS
(FR) COMPOSITIONS À BASE D'INHIBITEURS DE LA CHOLINESTÉRASE
Abstract: front page image
(EN) The present invention is directed to compositions, methods of use, and processes for the synthesis related to 3-((S)-l-(dimethylamino)ethyl)phenyl methyl-((R)- 1 -phenylpropan-2 yl)carbamate, and its pharmaceutically acceptable salt forms, including the hydrogen fumarate salt. The present invention also relates to a novel form polymorph of 3-((S)-l- (dimethylamino)ethyl)phenyl methyl-((R)- 1 -phenylpropan-2 yl)carbamate, characterized by a unique X-ray diffraction pattern and Differential Scanning Calorimetry profile, as well a unique crystalline structure.
(FR) La présente invention concerne des compositions, des procédés d'utilisation et des processus de synthèse associés au carbamate de 3-((S)-l-(diméthylamino) éthyl)phénylméthyl-((R)-1-phénylpropan-2-yle) et à ses sels pharmaceutiquement acceptables, dont le fumarate hydrogéné. La présente invention concerne également une forme polymorphe inédite du carbamate de 3-((S)-l-(diméthylamino)éthyl)phénylméthyl-((R)-1- phénylpropan-2-yle), caractérisée par un spectre de diffraction des rayons X, par un profil d'analyse calorimétrique différentielle et par une structure cristalline uniques.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)