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1. (WO2010115080) SELF-ASSEMBLING PEPTIDES BEARING ORGANIC ELECTRONIC FUNCTIONALITY AND APPLICATIONS EMPLOYING THE SAME
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2010/115080 International Application No.: PCT/US2010/029747
Publication Date: 07.10.2010 International Filing Date: 02.04.2010
IPC:
C07K 5/02 (2006.01) ,C07K 7/06 (2006.01) ,A61L 27/22 (2006.01) ,A61L 27/50 (2006.01) ,G01N 33/68 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
5
Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
02
containing at least one abnormal peptide link
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
7
Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04
Linear peptides containing only normal peptide links
06
having 5 to 11 amino acids
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27
Materials for prostheses or for coating prostheses
14
Macromolecular materials
22
Polypeptides or derivatives thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27
Materials for prostheses or for coating prostheses
50
Materials characterised by their function or physical properties
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68
involving proteins, peptides or amino acids
Applicants:
TOVAR, John, Dayton [US/US]; US (UsOnly)
DIEGELMANN, Stephen, Robert [US/US]; US (UsOnly)
WALL, Brian, D. [US/US]; US (UsOnly)
VADEHRA, Geeta, Sophie [US/US]; US (UsOnly)
THE JOHNS HOPKINS UNIVERSITY [US/US]; 3400 North Charles Street Baltimore, Maryland 21218, US (AllExceptUS)
Inventors:
TOVAR, John, Dayton; US
DIEGELMANN, Stephen, Robert; US
WALL, Brian, D.; US
VADEHRA, Geeta, Sophie; US
Agent:
CHILDERS, Jeffrey, W.; 100 North Charles Street, 5th Floor Baltimore, Maryland 21201, US
Priority Data:
61/202,77202.04.2009US
Title (EN) SELF-ASSEMBLING PEPTIDES BEARING ORGANIC ELECTRONIC FUNCTIONALITY AND APPLICATIONS EMPLOYING THE SAME
(FR) PEPTIDES À AUTO ASSEMBLAGE DOTÉS D'UNE FONCTIONNALITÉ ORGANO-ÉLECTRONIQUE, ET APPLICATIONS LES UTILISANT
Abstract:
(EN) The aqueous self-assembly of oligopeptide-flanked π-conjugated molecules into discrete one-dimensional nanostructures is described. Unique to these molecules is the fact that the π-conjugated unit has been directly embedded within the peptide backbone by way of a synthetic amino acid with π-functionality that is compatible with standard Fmoc-based peptide synthesis or by way of a diacid or other bis(electrophile) that can covalently cross-link peptide chains presented on a synthesis support. The peptide-based molecular designs enforce intimate π- π communication within the aggregates after charge-screening and self-assembly, making these nanostructures attractive for optical or electronic applications in biological environments. In other embodiments, a convenient method to incorporate π-electron units into peptides that assemble into amyloid-like supramolecular polymers is disclosed. Self-assembly manipulates these "electronic peptides" into delocalized sub-10 nm one dimensional (1-D) nanostructures under completely aqueous conditions.
(FR) La présente invention se rapporte à l'auto assemblage aqueux de molécules ?-conjuguées flanquées d'oligopeptides dans des nanostructures unidimensionnelles discrètes. Une caractéristique unique à ces molécules est que l'unité ?-conjuguée a été directement incorporée dans le squelette peptide au moyen d'un acide aminé synthétique doté d'une fonctionnalité ? qui est compatible avec une synthèse standard de peptides basés Fmoc ou au moyen d'un diacide ou d'un autre bis(électrophile) qui peut amener des chaînes de peptides présentées sur un support de synthèse à devenir réticulées de manière covalente. Les modèles moléculaires basés sur des peptides mettent en œuvre une communication ??? étroite à l'intérieur des agrégés après le tamisage de charge et l'auto-assemblage, ce qui rend ces nanostructures attractives dans le cadre d'applications optiques ou électroniques dans des environnements biologiques. Dans d'autres modes de réalisation, la présente invention se rapporte à un procédé simple d'utilisation consistant à incorporer des unités ?-électron dans des peptides qui s'assemblent en polymères supramoléculaires semblables à des amyloïdes. L'auto-assemblage manipule ces « peptides électroniques » dans des nanostructures unidimensionnelles (1-D) délocalisées de moins de 10 nm dans des conditions totalement aqueuses.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)