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1. (WO2010114971) COMPOUNDS FOR TREATING DISORDERS MEDIATED BY METABOTROPIC GLUTAMATE RECEPTOR 5, AND METHODS OF USE THEREOF

Pub. No.:    WO/2010/114971    International Application No.:    PCT/US2010/029575
Publication Date: Fri Oct 08 01:59:59 CEST 2010 International Filing Date: Fri Apr 02 01:59:59 CEST 2010
IPC: C07D 263/56
C07D 498/04
A61K 31/423
A61K 31/424
Applicants: DAINIPPON SUMITOMO PHARMA CO., LTD.
BURDI, Douglas
SPEAR, Kerry, L.
HARDY, Larry, Wendell
Inventors: BURDI, Douglas
SPEAR, Kerry, L.
HARDY, Larry, Wendell
Title: COMPOUNDS FOR TREATING DISORDERS MEDIATED BY METABOTROPIC GLUTAMATE RECEPTOR 5, AND METHODS OF USE THEREOF
Abstract:
Provided herein are compounds and methods of synthesis thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as neurological disorders, psychiatric disorders, neuromuscular disorders, gastrointestinal disorders, lower urinary tract disorder, and cancer. Compounds provided herein modulate the activity of metabotropic glutamate receptor 5 (mGluR5) in the central nervous system or the periphery. Pharmaceutical formulations containing the compounds and their methods of use are also provided herein.