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Machine translation
1. (WO2010114971) COMPOUNDS FOR TREATING DISORDERS MEDIATED BY METABOTROPIC GLUTAMATE RECEPTOR 5, AND METHODS OF USE THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/114971    International Application No.:    PCT/US2010/029575
Publication Date: 07.10.2010 International Filing Date: 01.04.2010
IPC:
C07D 263/56 (2006.01), C07D 498/04 (2006.01), A61K 31/423 (2006.01), A61K 31/424 (2006.01)
Applicants: DAINIPPON SUMITOMO PHARMA CO., LTD. [JP/JP]; 6-8 Dosho-machi 2-chome, Chuo-ku, Osaka-shi, Osaka 541-8524 (JP) (For All Designated States Except US).
BURDI, Douglas [US/US]; (US) (For US Only).
SPEAR, Kerry, L. [US/US]; (US) (For US Only).
HARDY, Larry, Wendell [US/US]; (US) (For US Only)
Inventors: BURDI, Douglas; (US).
SPEAR, Kerry, L.; (US).
HARDY, Larry, Wendell; (US)
Agent: INSOGNA, Anthony, M.; Jones Day 222 East 41st. Street New York, NY 10017-6702 (US)
Priority Data:
61/166,661 03.04.2009 US
61/255,790 28.10.2009 US
Title (EN) COMPOUNDS FOR TREATING DISORDERS MEDIATED BY METABOTROPIC GLUTAMATE RECEPTOR 5, AND METHODS OF USE THEREOF
(FR) COMPOSÉS UTILISABLES POUR LE TRAITEMENT DE TROUBLES À MÉDIATION PAR LE RÉCEPTEUR MÉTABOTROPIQUE 5 AU GLUTAMATE ET LEURS PROCÉDÉS D'UTILISATION
Abstract: front page image
(EN)Provided herein are compounds and methods of synthesis thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as neurological disorders, psychiatric disorders, neuromuscular disorders, gastrointestinal disorders, lower urinary tract disorder, and cancer. Compounds provided herein modulate the activity of metabotropic glutamate receptor 5 (mGluR5) in the central nervous system or the periphery. Pharmaceutical formulations containing the compounds and their methods of use are also provided herein.
(FR)La présente invention concerne des composés et leurs procédés de synthèse. Les composés de l'invention sont utilisables dans le cadre du traitement, de la prévention et/ou de la prise en charge de diverses affections, telles que des affections neurologiques, psychiatriques, neuromusculaires, gastro-intestinales, des affections touchant l'appareil urinaire inférieur et le cancer. Les composés de l'invention modulent l'activité du récepteur métabotropique 5 au glutamate (mGluR5) dans le système nerveux central ou périphérique. La présente invention concerne également des compositions pharmaceutiques contenant lesdits composés, ainsi que leurs procédés d'utilisation.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)