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1. (WO2010114930) METHODS OF USE FOR HSV-1 AND HSV-2 VACCINES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/114930    International Application No.:    PCT/US2010/029493
Publication Date: 07.10.2010 International Filing Date: 31.03.2010
IPC:
A61K 39/245 (2006.01)
Applicants: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA [US/US]; 3160 Chestnut Street-Suite 200 Philadelphia, PA 19104-6283 (US) (For All Designated States Except US).
FRIEDMAN, Harvey [US/US]; (US) (For US Only).
ZUMBRUN, Elizabeth, E. [US/US]; (US) (For US Only).
WANG, Fushan [US/US]; (US) (For US Only)
Inventors: FRIEDMAN, Harvey; (US).
ZUMBRUN, Elizabeth, E.; (US).
WANG, Fushan; (US)
Agent: COHEN, Mark, S.; Pearl Cohen Zedek Latzer, LLP 1500 Broadway, 12th Floor New York, NY 10036 (US)
Priority Data:
12/415,152 31.03.2009 US
Title (EN) METHODS OF USE FOR HSV-1 AND HSV-2 VACCINES
(FR) PROCÉDÉS D'UTILISATION DE VACCINS CONTRE VHS-1 ET VHS-2
Abstract: front page image
(EN)This invention provides methods of treating, suppressing, inhibiting, reducing an incidence, reducing the pathogenesis of, ameliorating the symptoms of, or ameliorating the secondary symptoms of a primary or recurring Herpes Simplex Virus (HSV) infection, or prolonging the latency to a relapse of an HSV infection, and disorders and symptoms associated with same and inducing an anti-HSV immune response in a subject comprising the step of contacting the subject with a composition comprising a mutant HSV strain comprising an inactivating mutation in a Us8 gene, followed by a second contacting with the composition.
(FR)Cette invention porte sur des procédés de traitement, de suppression, d'inhibition, de réduction d'une incidence, de réduction de la pathogenèse, d'amélioration des symptômes, ou d'amélioration des symptômes secondaires d'une infection primaire ou récurrente par le virus de l'Herpès (VHS), ou de prolongation de la latence d'une rechute d'une infection par le VHS, et de troubles et de symptômes associés à celui-ci et d'induction d'une réponse immunitaire anti-VHS dans un sujet, lesquels procédés comprennent les étapes de mise en contact du sujet avec une composition comprenant une souche de VHS mutante comprenant une mutation inactivante dans un gène Us8, suivie d'une seconde mise en contact avec la composition.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)