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1. (WO2010114894) SUBSTITUTED HETEROCYCLIC COMPOUNDS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2010/114894 International Application No.: PCT/US2010/029393
Publication Date: 07.10.2010 International Filing Date: 31.03.2010
IPC:
C07D 473/26 (2006.01) ,C07D 487/04 (2006.01) ,A61K 31/52 (2006.01) ,A61P 35/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
473
Heterocyclic compounds containing purine ring systems
26
with an oxygen, sulfur, or nitrogen atom directly attached in position 2 or 6, but not in both
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519
ortho- or peri-condensed with heterocyclic rings
52
Purines, e.g. adenine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
NICEWONGER, Robert [US/US]; US (UsOnly)
DALTON, Audra [US/US]; US (UsOnly)
BRASSARD, Chris [US/US]; US (UsOnly)
ASHWELL, Mark, A. [GB/US]; US (UsOnly)
PALMA, Rocio [AU/US]; US (UsOnly)
ARQULE, INC.; 19 Presidential Way Woburn, MA 01801, US (AllExceptUS)
Inventors:
NICEWONGER, Robert; US
DALTON, Audra; US
BRASSARD, Chris; US
ASHWELL, Mark, A.; US
PALMA, Rocio; US
Agent:
ELRIFI, Ivor, R.; Mintz Levin Cohn Ferris Glovsky And Popeo, P.C. One Financial Center Boston, MA 02111, US
Priority Data:
61/165,07531.03.2009US
61/165,12131.03.2009US
Title (EN) SUBSTITUTED HETEROCYCLIC COMPOUNDS
(FR) COMPOSÉS HÉTÉROCYCLIQUES SUBSTITUÉS
Abstract:
(EN) The present invention relates to substituted heterocyclic compounds and substituted tetrahydroisoquinoline compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted benzodiazepine compounds and substituted tetrahydroisoquinoline compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds or pharmaceutical compositions to subjects in need thereof.
(FR) La présente invention porte sur des composés hétérocycliques substitués et sur des composés tétrahydroisoquinoline substitués et sur des procédés de synthèse de ces composés. La présente invention porte également sur des compositions pharmaceutiques contenant des composés benzodiazépine substitués et des composés tétrahydroisoquinoline substitués et sur des procédés de traitement de troubles prolifératifs cellulaires, tels que le cancer, par l'administration de ces composés ou de ces compositions pharmaceutiques à des sujets en ayant besoin.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)