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1. (WO2010114828) METHODS AND COMPOSITIONS FOR TREATING SKIN CONDITIONS ASSOCIATED WITH VASCULAR HYPER-REACTIVITY
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2010/114828 International Application No.: PCT/US2010/029183
Publication Date: 07.10.2010 International Filing Date: 30.03.2010
IPC:
A61K 38/00 (2006.01) ,A61K 38/08 (2006.01) ,A61K 9/70 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
04
Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
08
Peptides having 5 to 11 amino acids
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
70
Web, sheet or filament bases
Applicants: HO, Connie L.[US/US]; US (UsOnly)
DU, Alice[US/US]; US (UsOnly)
BROWNE, Dan[US/US]; US (UsOnly)
REVANCE THERAPEUTICS, INC.[US/US]; 7555 Gateway Blvd. Newark, California 94560, US (AllExceptUS)
Inventors: HO, Connie L.; US
DU, Alice; US
BROWNE, Dan; US
Agent: TUSCAN, Michael S.; Cooley LLP 777 6th Street, NW Suite 1100 Washington, DC 20001, US
Priority Data:
61/165,70101.04.2009US
Title (EN) METHODS AND COMPOSITIONS FOR TREATING SKIN CONDITIONS ASSOCIATED WITH VASCULAR HYPER-REACTIVITY
(FR) PROCÉDÉ ET COMPOSITION DE TRAITEMENT DES AFFECTIONS DE LA PEAU ASSOCIÉES À UNE HYPERRÉACTIVITÉ VASCULAIRE
Abstract:
(EN) The present invention provides a methods and compositions for treating a patient having a skin condition characterized by vascular hyper-reactivity, such as chronic or episodic flushing or blushing, and/or rosacea. The method comprises applying a topical composition to affected areas of the patient's skin. The topical composition comprises an effective amount of a botulinum neurotoxin for decreasing vasodilation in cutaneous microvasculature, and a carrier for effectively transporting the botulinum toxin to the cutaneous microvasculature. The invention thereby provides a safe, effective, comfortable, and/or convenient manner of treating vascular hyper-reactivity in skin.
(FR) La présente invention porte sur des procédés et des compositions de traitement d'un patient ayant une affection caractérisée par une hyperréactivité vasculaire, telle qu'une bouffée congestive ou un rougissement chroniques ou épisodiques et/ou de l'acné. Le procédé comprend l'application d'une composition topique aux zones affectées de la peau du patient. La composition topique comprend une quantité efficace d'une neurotoxine botulique destinée à diminuer la vasodilatation dans la microvasculature cutanée et un support destiné à transporter efficacement la toxine botulinique vers la microvasculature cutanée. L'invention apporte ainsi une façon sûre, efficace, confortable et/ou commode de traitement d'une hyperréactivité vasculaire de la peau.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)