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1. (WO2010114797) PROTEIN-ASSISTED DRUG DELIVERY SYSTEM FOR THE TARGETED ADMINISTRATION OF ACTIVE AGENTS FOR OVERCOMING BLOOD-BRAIN BARRIER
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2010/114797 International Application No.: PCT/US2010/029065
Publication Date: 07.10.2010 International Filing Date: 29.03.2010
IPC:
A61K 9/127 (2006.01) ,A61K 38/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
10
Dispersions; Emulsions
127
Liposomes
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
Applicants: SONI, Vishal[US/US]; US (UsOnly)
PATEL, Kanaiyalal[US/US]; US (UsOnly)
LAKKARAJU, Dasaradhi[US/US]; US (UsOnly)
PURI, Navneet[US/US]; US (UsOnly)
INNOPHARMA, LLC[US/US]; 11 Deer Park Drive, Suite 205 Monmouth Junction, New Jersey 08852, US (AllExceptUS)
Inventors: SONI, Vishal; US
PATEL, Kanaiyalal; US
LAKKARAJU, Dasaradhi; US
PURI, Navneet; US
Agent: SKLAR, Steven; Leydig, Voit & Mayer, Ltd. 180 N. Stetson Ave., Suite 4900 Chicago, Illinois 60601, US
Priority Data:
61/165,41631.03.2009US
Title (EN) PROTEIN-ASSISTED DRUG DELIVERY SYSTEM FOR THE TARGETED ADMINISTRATION OF ACTIVE AGENTS FOR OVERCOMING BLOOD-BRAIN BARRIER
(FR) SYSTÈME D'ADMINISTRATION DE MÉDICAMENT ASSISTÉ PAR PROTÉINE POUR ADMINISTRATION CIBLÉE D'AGENTS ACTIFS DESTINÉS À SURMONTER LA BARRIÈRE HÉMATOENCÉPHALIQUE
Abstract:
(EN) The present invention provides a composition and prodrug for targeted drug delivery to the central nervous system of a patient. The inventive composition and prodrug include a pharmaceutically acceptable active agent and at least one protein selected from the group consisting of a fimbrial adhesin protein, a membrane protein, and combinations thereof. The inventive compositions and prodrugs of the present invention selectively target the blood-brain barrier and deliver hydrophilic and lipophilic active agents of varying sizes to the central nervous system.
(FR) La présente invention porte sur une composition et sur un promédicament pour administration ciblée de médicaments ciblée vers le système nerveux central d'un patient. La présente composition et le présent promédicament comprennent un agent actif pharmaceutiquement acceptable et au moins une protéine choisie dans le groupe constitué par une protéine adhésine de fimbriae, une protéine de membrane et des combinaisons de celles-ci. Les compositions et promédicaments innovants de la présente invention ciblent sélectivement la barrière hémato-encéphalique et administrent des agents actifs hydrophiles et lipophiles de diverses dimensions au système nerveux central.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)