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1. (WO2010114710) An artificial micro-gland
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2010/114710 International Application No.: PCT/US2010/027751
Publication Date: 07.10.2010 International Filing Date: 18.03.2010
IPC:
A61K 9/16 (2006.01) ,A61K 9/14 (2006.01) ,A61K 9/127 (2006.01) ,A61K 9/06 (2006.01) ,A61K 47/30 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
14
Particulate form, e.g. powders
16
Agglomerates; Granulates; Microbeadlets
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
14
Particulate form, e.g. powders
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
10
Dispersions; Emulsions
127
Liposomes
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
06
Ointments; Bases therefor
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
30
Macromolecular compounds
Applicants:
MARQUEZ, Manuel [US/US]; US
MARQUEZ, Samantha [US/US]; US
GARCIA, Antonio [US/US]; US
Inventors:
MARQUEZ, Manuel; US
MARQUEZ, Samantha; US
GARCIA, Antonio; US
Agent:
VENTRE, Louis, Jr.; 2483 Oakton Hills Dr. Oakton, Virginia 22124, US
Priority Data:
61/165,98902.04.2009US
61/257,66603.11.2009US
Title (EN) An artificial micro-gland
(FR) GLANDE ARTIFICIELLE MICROSCOPIQUE
Abstract:
(EN) A micro-scale artificial gland is disclosed in the form of an independent unit for promoting biological activity. The artificial gland includes cells formed in a membrane enclosing a reservoir. The reservoir is a bio-reactor capable of containing a product of activity of the cells. The reservoir comprises a gas, a liquid, and a gel and preferably also contains nanoparticles, a buffer, a surfactant, and, a gel precursor. The reservoir may also contain cells. Nanoparticles may also surround the artificial gland to form a protective coating. A variety of methods are disclosed for making the artificial gland by directed assembly of cells into the artificial micro-gland by gel, liquid or bubble templating. All involve coating the surface of gel, droplet or bubble with the living cells and the stabilizing the cells on the surface of gels, droplets or bubbles.
(FR) La présente invention concerne une glande artificielle à échelle microscopique sous forme d'unité indépendante favorisant l'activité biologique. La glande artificielle comprend des cellules formées dans une membrane entourant un réservoir. Le réservoir est un bioréacteur pouvant contenir un produit d'activité des cellules. Le réservoir comprend un gaz, un liquide, et un gel, et de préférence comprend également des nanoparticules, un tampon, un agent de surface, et un précurseur en gel. Le réservoir peut également contenir des cellules. Des nanoparticules peuvent également entourer la glande artificielle pour former un revêtement de protection. De nombreux procédés sont décrits pour réaliser la glande artificielle grâce à des ensembles dirigés de cellules dans la glande microscopique par échantillonnage de gel, gouttelette ou bulle. Tout ceci implique de recouvrir la surface de gel, gouttelette ou bulle, avec les cellules vivantes, et de stabiliser les cellules sur la surface des gels, gouttelettes ou bulles.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)