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1. (WO2010114629) FORMULATION

Pub. No.:    WO/2010/114629    International Application No.:    PCT/US2010/001018
Publication Date: Fri Oct 08 01:59:59 CEST 2010 International Filing Date: Tue Apr 06 01:59:59 CEST 2010
IPC: A61K 9/127
A61K 39/395
A61P 31/18
A61P 31/12
Applicants: DUKE UNIVERSITY
CHILDREN'S MEDICAL CENTER CORPORATION
ALAM, Munir
HAYNES, Barton, F.
HARRISON, Stephen
CHEN, Bing
Inventors: ALAM, Munir
HAYNES, Barton, F.
HARRISON, Stephen
CHEN, Bing
Title: FORMULATION
Abstract:
The present invention relates, in general, to a formulation suitable for use in inducing anti-HIV-1 antibodies and, in particular, to a formulation comprising a prehairpin intermediate form of HIV-1 envelope gp41 linked to a liposome. The invention also relates to methods of inducing broadly neutralizing anti-HIV-1 antibodies using such a formulation.