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1. (WO2010114628) FORMULATION FOR INDUCING BROADLY REACTIVE NEUTRALIZING ANTI-HIV ANTIBODIES
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2010/114628 International Application No.: PCT/US2010/001017
Publication Date: 07.10.2010 International Filing Date: 05.04.2010
IPC:
A61K 38/16 (2006.01) ,A61K 38/08 (2006.01) ,A61P 31/18 (2006.01) ,A61P 31/12 (2006.01)
Applicants: ALAM, S., Munir[US/US]; US (UsOnly)
HAYNES, Barton, F.[US/US]; US (UsOnly)
SEKARAN, Moses, D.[IN/US]; US (UsOnly)
TOMARAS, Georgia[US/US]; US (UsOnly)
SHEN, Xiaoying[CN/US]; US (UsOnly)
DUKE UNIVERSITY[US/US]; Durham, NC 27710, US (AllExceptUS)
Inventors: ALAM, S., Munir; US
HAYNES, Barton, F.; US
SEKARAN, Moses, D.; US
TOMARAS, Georgia; US
SHEN, Xiaoying; US
Agent: WILSON, Mary, J.; Nixon & Vanderhye P.C. 901 North Glebe Road, 11th Floor Arlington, VA 22203-1808, US
Priority Data:
61/166,62503.04.2009US
Title (EN) FORMULATION FOR INDUCING BROADLY REACTIVE NEUTRALIZING ANTI-HIV ANTIBODIES
(FR) COMPOSITION CAPABLE D'INDUIRE LA PRODUCTION D'ANTICORPS NEUTRALISANTS TRÈS RÉACTIFS CONTRE LE VIH
Abstract:
(EN) The present invention relates in general, to a formulation suitable for use in inducing anti-HIV-1 antibodies, and, in particular, to a formulation comprising Toll Like Receptor (TLR) agonists with HIV-1 gp41 membrane proximal external region (MPER) peptide-liposome conjugates for induction of broadly reactive anti-HIV-1 antibodies. The invention also relates to methods of inducing neutralizing anti-HIV-1 antibodies using such formulations.
(FR) La présente invention concerne, de façon générale, une composition pouvant être utilisée pour induire la production d'anticorps contre le VIH-1 et, en particulier, une composition comprenant des agonistes du récepteur de type Toll (TLR) et des conjugués associant peptides du domaine MPER de la protéine gp41 du VIH-1 et liposomes, en vue de l'induction de la production d'anticorps très réactifs contre le VIH-1. L'invention concerne également des procédés d'induction de la production d'anticorps neutralisants contre le VIH-1 au moyen de ladite composition.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)