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1. (WO2010114539) TUMOR TARGETING PEPTIDES, THERAPEUTIC AND DIAGNOSTIC COMPOSITIONS COMPRISING THE PEPTIDES
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2010/114539 International Application No.: PCT/US2009/039197
Publication Date: 07.10.2010 International Filing Date: 01.04.2009
IPC:
C07K 14/435 (2006.01) ,C07K 19/00 (2006.01) ,A61K 47/48 (2006.01) ,A61P 35/00 (2006.01)
Applicants: SCHMIDT-WOLF, Ingo[DE/DE]; DE
MESSMER, Davorka[US/US]; US (UsOnly)
Inventors: SCHMIDT-WOLF, Ingo; DE
MESSMER, Davorka; US
Agent: SKAUGSET, Anton, E.; Kolisch Hartwell, P.C. 520 S.W. Yamhill Street Suite 200 Portland, OR 97204, US
Priority Data:
Title (EN) TUMOR TARGETING PEPTIDES, THERAPEUTIC AND DIAGNOSTIC COMPOSITIONS COMPRISING THE PEPTIDES
(FR) PEPTIDES CIBLANT UNE TUMEUR, COMPOSITIONS THÉRAPEUTIQUES ET DE DIAGNOSTIC COMPRENANT LES PEPTIDES
Abstract: front page image
(EN) The present invention is directed to peptides having affinity for tumor cells. The peptides are useful in pharmaceutical compositions in particular for the treatment of cancer. Further, the peptides are useful in diagnostic compositions, in particular for the diagnosis and imaging of cancer. The peptides according to the present invention are peptides selected from the group consisting of: Z1-KLAKLAKKLAKLAK-Z2-LTVXPWY-Z3, Z1-KLAKLAKKLAKLAK-Z2-LTVXP-Z3, Z1-KLAKLAKKLAKLAK-Z2-TVXPW-Z3, Z1-KLAKLAKKLAKLAK-Z2-VXPWY-Z3, Z1-KLAKLAKKLA KLAK-Z2-XPWY-Z3, Z1-KLAKLAKKLAKLAK-Z2-LTVXPW-Z3, di-, tri-, or multimers of the above sequences, wherein each Z1, Z2 and Z3 independently of one another represents any amino acid sequence of n amino acids, n varying from 0 to 50 and n being identical or different in Z1, Z2, and Z3, and wherein X represents any amino acid, whereby each of the amino acid residues in the above sequences may be independently in either L-form or D-form.
(FR) La présente invention porte sur des peptides présentant une affinité pour des cellules tumorales. Les peptides sont utiles dans des compositions pharmaceutiques, en particulier pour le traitement du cancer. En outre, les peptides sont utiles dans des compositions de diagnostic, en particulier pour le diagnostic et l'imagerie d'un cancer. Les peptides selon la présente invention sont des peptides choisies dans le groupe constitué par : Z1-KLAKLAKKLAKLAK-Z2-LTVXPWY-Z3, Z1-KLAKLAKKLAKLAK-Z2-LTVXP-Z3, Z1-KLAKLAKKLAKLAK-Z2-TVXPW-Z3, Z1-KLAKLAKKLAKLAK-Z2-VXPWY-Z3, Z1-KLAKLAKKLA KLAK-Z2-XPWY-Z3, Z1-KLAKLAKKLAKLAK-Z2-LTVXPW-Z3, des di-, tri-, ou multimères des séquences ci-dessus, dans lesquelles chaque Z1, Z2 et Z3 représente indépendamment n'importe quelle séquence d'acide aminé de n acides aminés, n variant de 0 à 50 et n étant identique ou différent dans Z1, Z2 et Z3, et dans lesquelles X représente n'importe quel acide aminé, chacun des résidus d'acides aminés dans les séquences ci-dessus pouvant indépendamment se trouver sous la forme L ou sous la forme D.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)