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1. (WO2010114533) ANTI-BIOFILM CARBONATE COMPOUNDS FOR USE IN ORAL CARE COMPOSITIONS

Pub. No.:    WO/2010/114533    International Application No.:    PCT/US2009/039140
Publication Date: Fri Oct 08 01:59:59 CEST 2010 International Filing Date: Thu Apr 02 01:59:59 CEST 2009
IPC: A61K 31/265
A61P 1/02
A61P 31/04
Applicants: COLGATE-PALMOLIVE COMPANY
TRIVEDI, Harsh, M.
MIKSA, Davide
XU, Tao
Inventors: TRIVEDI, Harsh, M.
MIKSA, Davide
XU, Tao
Title: ANTI-BIOFILM CARBONATE COMPOUNDS FOR USE IN ORAL CARE COMPOSITIONS
Abstract:
The present invention includes oral care compositions and methods for inhibiting growth and formation of oral biofilms by quorum sensing inhibition and/or bactericidal activity. In some embodiments, the present invention discloses an oral care composition including a therapeutically effective amount of at least one carbonate compound of Formula (1) and at least one excipient: wherein, R1 and R2 are independently: an aliphatic radical; a hydroxyaliphatic radical; or an aryl radical. In some embodiments, the present invention discloses a method of providing oral care benefits including applying to an oral cavity an oral care composition containing a therapeutically effective amount of at least one carbonate compound of Formula (1) and at least one excipient. In some embodiments, the present invention discloses a method of up- regulating or down-regulating periodontal disease metabolites including applying to an oral cavity an oral care composition containing a therapeutically effective amount of at least on carbonate compound of Formula (1) and at least one excipient.