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1. (WO2010114297) MICROSPHERE HAVING HOT SPOTS AND METHOD FOR IDENTIFYING CHEMICALS THROUGH SURFACE ENHANCED RAMAN SCATTERING USING THE SAME
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Pub. No.:
WO/2010/114297
International Application No.:
PCT/KR2010/001958
Publication Date:
07.10.2010
International Filing Date:
31.03.2010
IPC:
G01N 21/65
(2006.01),
G01N 33/553
(2006.01)
G
PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21
Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible, or ultra-violet light
62
Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
63
optically excited
65
Raman scattering
G
PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
543
with an insoluble carrier for immobilising immunochemicals
551
the carrier being inorganic
553
Metal or metal coated
Applicants:
PARK, Se Jin
[KR/KR]; (KR).
CHUNG, Taek Dong
[KR/KR]; (KR).
PIAO, Lilin
[CN/KR]; (KR).
BOO, Han Kil
[KR/KR]; (KR)
Inventors:
PARK, Se Jin
; (KR).
CHUNG, Taek Dong
; (KR).
PIAO, Lilin
; (KR).
BOO, Han Kil
; (KR)
Agent:
KIM, Jinhak
; #1104, Kumsan Bldg., 17-1 Youido-dong, Youngdeungpo-ku Seoul 150-727 (KR)
Priority Data:
10-2009-0027800
31.03.2009
KR
Title
(EN)
MICROSPHERE HAVING HOT SPOTS AND METHOD FOR IDENTIFYING CHEMICALS THROUGH SURFACE ENHANCED RAMAN SCATTERING USING THE SAME
(FR)
MICROSPHÈRE AYANT DES POINTS CHAUDS ET PROCÉDÉ D'IDENTIFICATION DE PRODUITS CHIMIQUES PAR DIFFUSION RAMAN EXALTÉE EN SURFACE LES UTILISANT
Abstract:
(EN)
The present invention relates to the microsphere whose surface is covered with hot spots and the method for identifying chemicals through Surface Enhanced Raman Scattering (SERS) using the same. The microsphere having hot spots, according to the present invention, includes a microsphere and metal networks as a shell which covers the surface of the microsphere, and nano-sized pores are distributed randomly on the surface or in the interstitial space of the metal networks. The microsphere having hot spots, according to the present invention, can be individually manipulated under a conventional optical microscope. SERS spectra of the monolayer of molecules on Pt or Au can be measured using single microsphere having hot spots mentioned as a sensitive probe. The microsphere having hot spots can be applied for decoding the microspheres with Raman tags flowing in a microfluidic system.
(FR)
La présente invention porte sur une microsphère dont la surface est recouverte de points chauds et sur un procédé d'identification de produits chimiques par diffusion Raman exaltée de surface (SERS) les utilisant. La microsphère ayant des points chauds selon la présente invention comprend une microsphère et des réseaux métalliques comme une coque qui recouvre la surface de la microsphère, et des pores de dimension nanoscopique sont répartis de façon aléatoire sur la surface ou dans l'espace interstitiel des réseaux métalliques. La microsphère ayant des points chauds selon la présente invention peut être manipulée individuellement sous un microscope optique classique. Des spectres de SERS de la monocouche de molécules sur Pt ou Au peuvent être mesurés à l'aide, comme sonde sensible, d'une unique microsphère ayant des points chauds mentionnée. La microsphère ayant des points chauds peut être appliquée au décodage des microsphères avec des étiquettes Raman s'écoulant dans un système microfluidique.
Designated States:
AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language:
English (
EN
)
Filing Language:
English (
EN
)