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1. (WO2010114106) MONOCLONAL ANTIBODY CAPABLE OF BINDING TO SPECIFIC DISCONTINUOUS EPITOPE OCCURRING IN AD1 REGION OF HUMAN CYTOMEGALOVIRUS GB GLYCOPROTEIN, AND ANTIGEN-BINDING FRAGMENT THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2010/114106 International Application No.: PCT/JP2010/056037
Publication Date: 07.10.2010 International Filing Date: 01.04.2010
Chapter 2 Demand Filed: 27.12.2010
IPC:
C12N 15/09 (2006.01) ,A61K 39/395 (2006.01) ,A61P 1/04 (2006.01) ,A61P 1/16 (2006.01) ,A61P 7/00 (2006.01) ,A61P 11/00 (2006.01) ,A61P 15/06 (2006.01) ,A61P 25/00 (2006.01) ,A61P 25/18 (2006.01) ,A61P 25/28 (2006.01) ,A61P 27/02 (2006.01) ,A61P 31/22 (2006.01) ,C07K 16/08 (2006.01) ,C12N 1/15 (2006.01) ,C12N 1/19 (2006.01) ,C12N 1/21 (2006.01) ,C12N 5/10 (2006.01) ,C12P 21/08 (2006.01)
Applicants: TAKADA Kenzo[JP/JP]; JP (UsOnly)
KURINO Rika[JP/JP]; JP (UsOnly)
TORASHIMA Takashi[JP/JP]; JP (UsOnly)
EVEC INCORPORATED[JP/JP]; 8, Odori Nishi 5-chome, Chuo-ku, Sapporo-shi, Hokkaido 0600042, JP (AllExceptUS)
Inventors: TAKADA Kenzo; JP
KURINO Rika; JP
TORASHIMA Takashi; JP
Agent: KOBAYASHI Hiroshi; ABE, IKUBO & KATAYAMA, Fukuoka Bldg. 9th Fl., 8-7, Yaesu 2-chome, Chuo-ku, Tokyo 1040028, JP
Priority Data:
2009-08944201.04.2009JP
Title (EN) MONOCLONAL ANTIBODY CAPABLE OF BINDING TO SPECIFIC DISCONTINUOUS EPITOPE OCCURRING IN AD1 REGION OF HUMAN CYTOMEGALOVIRUS GB GLYCOPROTEIN, AND ANTIGEN-BINDING FRAGMENT THEREOF
(FR) ANTICORPS MONOCLONAL POUVANT SE LIER À UN ÉPITOPE DISCONTINU SPÉCIFIQUE APPARAISSANT DANS UNE RÉGION AD1 D'UNE GLYCOPROTÉINE gB DE CYTOMÉGALOVIRUS HUMAIN, ET FRAGMENT DE LIAISON À UN ANTIGÈNE DUDIT ANTICORPS
(JA) ヒトサイトメガロウイルスgB糖タンパク質のAD1領域に存在する特定の不連続エピトープに結合するモノクローナル抗体ならびにその抗原結合性断片
Abstract:
(EN) Disclosed are: a pharmaceutical composition which comprises a monoclonal antibody capable of binding specifically to an AD1 region of gB glycoprotein of human cytomegalovirus (HCMV) (which is a virus causing various disease conditions) and having an excellent neutralizing ability for HCMV and an antigen-binding fragment of the monoclonal antibody; a monoclonal antibody which can bind specifically to a discontinuous sequence occurring in an AD1 region of HCMV and has an excellent neutralizing ability for HCMV and an inhibitory ability on the intercellular infection of HCMV, and an antigen-binding fragment of the monoclonal antibody; a pharmaceutical composition comprising the antibody or a fragment thereof; and others.
(FR) L'invention concerne une composition pharmaceutique comprenant un anticorps monoclonal pouvant se lier spécifiquement à une région AD1 d'une glycoprotéine gB de cytomégalovirus humain (HCMV) (virus causant des affections variées) et présentant une excellente capacité à neutraliser le HCMV, et un fragment de liaison à un antigène de cet anticorps monoclonal. L'invention concerne également un anticorps monoclonal pouvant se lier spécifiquement à une séquence discontinue apparaissant dans une région AD1 de cytomégalovirus humain et présentant une excellente capacité à neutraliser le HCMV et une activité inhibitrice sur une infection intercellulaire HCMV; et un fragment de liaison à un antigène de cet anticorps monoclonal. L'invention concerne également une composition pharmaceutique comprenant ledit anticorps ou un fragment de celui-ci; et analogues.
(JA)  本発明は、様々な疾病状態を導く原因となるヒトサイトメガロウイルスHCMVに対し、gB糖タンパク質のAD1領域に特異的に結合し、優れた中和能を有するモノクローナル抗体およびその抗原結合性断片を含む医薬組成物を提供する。本発明は、HCMVに対して、AD1領域の不連続配列に特異的に結合する中和能および細胞間感染阻止能の優れたモノクローナル抗体ならびにその抗原結合断片、その抗体または断片を含む医薬組成物等を提供する。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)