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1. (WO2010114013) POLYION COMPLEX OF DOUBLE-STRANDED RIBONUCLEIC ACID
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2010/114013 International Application No.: PCT/JP2010/055826
Publication Date: 07.10.2010 International Filing Date: 31.03.2010
IPC:
C12N 15/113 (2010.01) ,A61K 31/713 (2006.01) ,A61K 47/34 (2006.01) ,A61K 48/00 (2006.01) ,C12N 15/09 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
113
Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7088
Compounds having three or more nucleosides or nucleotides
713
Double-stranded nucleic acids or oligonucleotides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
30
Macromolecular compounds
34
Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
Applicants:
堀 雄一 HORI, Yuichi [JP/JP]; JP (UsOnly)
片岡 一則 KATAOKA, Kazunori [JP/JP]; JP (UsOnly)
藤田 敏郎 FUJITA, Toshiro [JP/JP]; JP (UsOnly)
清水 英樹 SHIMIZU, Hideki [JP/JP]; JP (UsOnly)
要 伸也 KANAME, Shinya [JP/JP]; JP (UsOnly)
松本 悟 MATSUMOTO, Satoru [JP/JP]; JP (UsOnly)
西山 伸宏 NISHIYAMA, Nobuhiro [JP/JP]; JP (UsOnly)
宮田 完二郎 MIYATA, Kanjiro [JP/JP]; JP (UsOnly)
大庭 誠 OBA, Makoto [JP/JP]; JP (UsOnly)
国立大学法人 東京大学 THE UNIVERSITY OF TOKYO [JP/JP]; 東京都文京区本郷七丁目3番1号 3-1, Hongo 7-chome, Bunkyo-ku, Tokyo 1138654, JP (AllExceptUS)
Inventors:
堀 雄一 HORI, Yuichi; JP
片岡 一則 KATAOKA, Kazunori; JP
藤田 敏郎 FUJITA, Toshiro; JP
清水 英樹 SHIMIZU, Hideki; JP
要 伸也 KANAME, Shinya; JP
松本 悟 MATSUMOTO, Satoru; JP
西山 伸宏 NISHIYAMA, Nobuhiro; JP
宮田 完二郎 MIYATA, Kanjiro; JP
大庭 誠 OBA, Makoto; JP
Agent:
高島 一 TAKASHIMA, Hajime; 大阪府大阪市中央区伏見町四丁目1番1号 明治安田生命大阪御堂筋ビル Meiji Yasuda Seimei Osaka Midosuji Bldg., 1-1, Fushimimachi 4-chome, Chuo-ku, Osaka-shi, Osaka 5410044, JP
Priority Data:
2009-08517631.03.2009JP
Title (EN) POLYION COMPLEX OF DOUBLE-STRANDED RIBONUCLEIC ACID
(FR) COMPLEXE POLYIONIQUE D'ACIDE RIBONUCLÉIQUE DOUBLE BRIN
(JA) 二本鎖リボ核酸ポリイオンコンプレックス
Abstract:
(EN) Disclosed are a delivery system useful for delivering a double-stranded ribonucleic acid that achieves gene silencing in glomeruli, particularly mesangial cells or other cells to the tissues or cells; and others. Specifically disclosed is a polyion complex in the form of a non-polymeric micelle, which comprises a double-stranded ribonucleic acid and a block copolymer represented by general formula (I) or (II) electrostatically coupled to each other and has an average particle diameter measured by a dynamic light scattering method of less than 100 nm. The definitions of the symbols in formulae (I) and (II) are the same as in the description.
(FR) L'invention porte sur un système de distribution utile pour distribuer un acide ribonucléique double brin qui réalise un silençage de gène dans les glomérules, en particulier les cellules mésangiales ou autres cellules, pour les tissus ou cellules ; et autres. L'invention porte spécifiquement sur un complexe polyionique sous la forme d'une micelle non polymère, qui comprend un acide ribonucléique double brin et un copolymère à blocs représenté par la formule générale (I) ou (II) électrostatiquement couplés entre eux et a un diamètre moyen de particule mesuré par un procédé de diffusion dynamique de la lumière de moins de 100 nm. Les définitions des symboles dans les formules (I) et (II) sont les mêmes que dans la description.
(JA)  糸球体、特にメサンギウム細胞などにおける遺伝子サイレンシングに機能する二本鎖リボ核酸の当該組織又は細胞への送達に有用なデリバリーシステムなどを提供する。二本鎖リボ核酸と、下記一般式(I)又は(II)で表されるブロック共重合体とが静電結合されてなる非高分子ミセル形態のポリイオンコンプレックスであって、動的光散乱測定法で測定した場合に100nm未満の平均粒径を有するポリイオンコンプレックス。(式中の記号の定義は、明細書に記載の通りである。)
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)