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1. (WO2010113937) PROCESS FOR PRODUCING NUCLEOSIDE
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2010/113937 International Application No.: PCT/JP2010/055670
Publication Date: 07.10.2010 International Filing Date: 30.03.2010
IPC:
C07H 19/16 (2006.01) ,C07F 7/18 (2006.01) ,C07H 23/00 (2006.01) ,C07B 61/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19
Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro derivatives thereof
02
sharing nitrogen
04
Heterocyclic radicals containing only nitrogen as ring hetero atom
16
Purine radicals
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
F
ACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
7
Compounds containing elements of the 4th Group of the Periodic System
02
Silicon compounds
08
Compounds having one or more C-Si linkages
18
Compounds having one or more C-Si linkages as well as one or more C-O-Si linkages
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
23
Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
B
GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
61
Other general methods
Applicants: UMEMOTO, Tadashi[JP/JP]; JP (UsOnly)
HAYASE, Yoji[JP/JP]; JP (UsOnly)
MURATA, Shumpei[JP/JP]; JP (UsOnly)
MIYATA, Kenichi[JP/JP]; JP (UsOnly)
TAKEDA PHARMACEUTICAL COMPANY LIMITED[JP/JP]; 1-1, Doshomachi 4-chome, Chuo-ku, Osaka-shi, Osaka 5410045, JP (AllExceptUS)
Inventors: UMEMOTO, Tadashi; JP
HAYASE, Yoji; JP
MURATA, Shumpei; JP
MIYATA, Kenichi; JP
Agent: TAKASHIMA, Hajime; Meiji Yasuda Seimei Osaka Midosuji Bldg., 1-1, Fushimimachi 4-chome, Chuo-ku, Osaka-shi, Osaka 5410044, JP
Priority Data:
2009-08589731.03.2009JP
Title (EN) PROCESS FOR PRODUCING NUCLEOSIDE
(FR) PROCÉDÉ DE PRODUCTION DE NUCLÉOSIDE
(JA) ヌクレオシドの製造方法
Abstract:
(EN) A process for producing an NC-type purine nucleoside readily has been demanded. Thus, disclosed is a process for producing a purine nucleoside represented by formula (I') or a salt thereof, which comprises reacting a pyrimidine nucleoside represented by formula (I) or a salt thereof with a purine nucleic acid base represented by formula: B'H in the presence of a Lewis acid.
(FR) L'invention porte sur un procédé de production aisée d'un nucléoside purique de type NC. Ainsi, l'invention porte sur un procédé de production d'un nucléoside purique représenté par la formule (I') ou d'un sel de celui-ci, qui comprend la réaction d'un nucléoside pyrimidique représenté par la formule (I) ou un sel de celui-ci avec une base d'acide nucléique purique représentée par la formule : B'H en présence d'un acide de Lewis.
(JA)  NC型プリンヌクレオシドを簡便に製造する方法が求められている。 式(I)で表されるピリミジンヌクレオシドまたはその塩を、ルイス酸存在下で、式B'Hで表されるプリン核酸塩基と反応させることを特徴とする、式(I')で表されるプリンヌクレオシドまたはその塩を製造する方法。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)