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1. (WO2010113906) MET INHIBITOR COMPRISING EPHEDRAE HERBA
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/113906    International Application No.:    PCT/JP2010/055622
Publication Date: 07.10.2010 International Filing Date: 30.03.2010
Chapter 2 Demand Filed:    29.07.2010    
IPC:
A61K 36/00 (2006.01), A61P 35/00 (2006.01), A61P 35/04 (2006.01), A61P 43/00 (2006.01)
Applicants: THE KITASATO INSTITUTE [JP/JP]; 9-1, Shirokane 5-chome, Minato-ku, Tokyo 1088641 (JP) (For All Designated States Except US).
JAPAN HEALTH SCIENCES FOUNDATION [JP/JP]; 13-4, Nihonbashi Kodenma-cho, Chuo-ku, Tokyo 1030001 (JP) (For All Designated States Except US).
HANAWA, Toshihiko [JP/JP]; (JP) (For US Only).
HYUGA, Sumiko [JP/JP]; (JP) (For US Only).
HYUGA, Masashi [JP/JP]; (JP) (For US Only)
Inventors: HANAWA, Toshihiko; (JP).
HYUGA, Sumiko; (JP).
HYUGA, Masashi; (JP)
Agent: SHIMIZU, Hatsushi; Kantetsu Tsukuba Bldg. 6F, 1-1-1, Oroshi-machi, Tsuchiura-shi, Ibaraki 3000847 (JP)
Priority Data:
2009-086363 31.03.2009 JP
Title (EN) MET INHIBITOR COMPRISING EPHEDRAE HERBA
(FR) INHIBITEUR DE MET COMPRENANT EPHEDRAE HERBA
(JA) 麻黄を成分とするMET阻害剤
Abstract: front page image
(EN)Provided is an MET inhibitor which comprises Epherdae herba (mao) or a Chinese crude drug containing E. herba. It is found out that an E. herba-based preparation (mao-to) or E. herba inhibits the tyrosine phosphorylation of MET and thus strongly suppresses the HGF-MET signaling. It is also clarified that these inhibitory activities are caused by E. herba that is a crude drug constituting the E. herba-based preparation. By inhibiting the HGF-MET signaling, E. herba suppresses the proliferation, infiltration and metastasis of MET-expressing cancer cells.
(FR)L'invention porte sur un inhibiteur de MET qui comprend Ephedrae herba (mao) ou un médicament brut chinois contenant E. herba. Il est trouvé qu'une préparation à base de E. herba (mao-to) ou E. herba inhibe la phosphorylation de tyrosine de MET et ainsi supprime fortement la signalisation HGF-MET. Il est également clarifié que ces activités inhibitrices sont provoquées par E. herba qui est un médicament brut constituant la préparation à base de E. herba. En empêchant la signalisation HGF-MET, E. herba supprime la prolifération, l'infiltration et les métastases de cellules cancéreuses exprimant MET.
(JA) 本発明者らは、麻黄湯や麻黄が、MET のチロシンリン酸化を阻害することでHGF-METシグナリングを強力に抑制することを発見した。また、これらの阻害活性は、麻黄湯の構成生薬の麻黄に由来することを突き止めた。麻黄はHGF-METシグナリングを阻害することにより、MET発現癌細胞の増殖、浸潤及び転移を抑制する。本発明は、麻黄、あるいは麻黄を含有する漢方薬を成分とするMET阻害剤を提供する。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)