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Pub. No.:    WO/2010/113860    International Application No.:    PCT/JP2010/055546
Publication Date: 07.10.2010 International Filing Date: 29.03.2010
C07D 207/06 (2006.01), A61K 31/397 (2006.01), A61K 31/40 (2006.01), A61K 31/4025 (2006.01), A61K 31/403 (2006.01), A61P 1/02 (2006.01), A61P 3/14 (2006.01), A61P 5/18 (2006.01), A61P 19/02 (2006.01), A61P 19/08 (2006.01), A61P 19/10 (2006.01), A61P 29/00 (2006.01), A61P 35/00 (2006.01), A61P 43/00 (2006.01), C07D 205/04 (2006.01), C07D 207/08 (2006.01), C07D 207/10 (2006.01), C07D 207/12 (2006.01), C07D 207/20 (2006.01), C07D 209/52 (2006.01), C07D 405/06 (2006.01), C07D 409/06 (2006.01), C07D 409/12 (2006.01)
Applicants: DAIICHI SANKYO COMPANY,LIMITED [JP/JP]; 3-5-1,Nihonbashi Honcho,Chuo-ku, Tokyo 1038426 (JP) (For All Designated States Except US).
NAKAO, Akira; (For US Only).
GOTANDA,Kentoku; (For US Only).
AOKI,Kazumasa; (For US Only).
KANEKO, Satoru; (For US Only).
ARITA, Tsuyoshi; (For US Only).
FUJIMOTO,Teppei; (For US Only).
HIRUMA,Yoshiharu; (For US Only).
SHIIKI,Takeshi; (For US Only).
STEPHEN Matin Courtney; (For US Only).
CHRISTPHER John Yarnold; (For US Only).
REBECCA Davie; (For US Only).
SUGANTHAN Selvaratnam; (For US Only)
Inventors: NAKAO, Akira; .
GOTANDA,Kentoku; .
AOKI,Kazumasa; .
KANEKO, Satoru; .
ARITA, Tsuyoshi; .
FUJIMOTO,Teppei; .
HIRUMA,Yoshiharu; .
SHIIKI,Takeshi; .
STEPHEN Matin Courtney; .
CHRISTPHER John Yarnold; .
REBECCA Davie; .
SUGANTHAN Selvaratnam;
Agent: ISHIBASHI Koki; c/o DAIICHI SANKYO COMPANY, LIMITED, 1-16-13,Kitakasai, Edogawa-ku, Tokyo 1340081 (JP)
Priority Data:
2009-084858 31.03.2009 JP
(JA) ビフェニル-環状アミン化合物
Abstract: front page image
(EN)Disclosed is a novel compound that has an antagonist action on a calcium receptor. Specifically disclosed is a compound represented by general formula (I) or a pharmacologically acceptable salt thereof. (In the formula, the substituents are defined as follows: R1, R1', R2 and R3 each represents a hydrogen atom or the like; Ar represents a phenyl group or the like; n represents 1 or the like; and m represents 1 or the like.)
(FR)L'invention porte sur un nouveau composé qui a une action antagoniste sur un récepteur du calcium. De manière spécifique, l'invention porte sur un composé représenté par la formule générale (I) ou sur un sel pharmacologiquement acceptable de celui-ci. (Dans la formule, les substituants sont définis comme suit : R1, R1', R2 et R3 représentent chacun un atome d'hydrogène ou similaire ; Ar représente un groupe phényle ou similaire ; n représente 1 ou similaire ; et m représente 1 similaire).
(JA)カルシウム受容体アンタゴニスト作用をする新規な化合物を提供することが課題である。 解決手段は、一般式(I)を有する化合物又はその薬理上許容される塩である。 [式中、各置換基は以下のように定義ざれる。R、R1'、R2、及びRは、水素原子等を示す。Arは、フェニル基等を示す。nは、1等を示す。mは、1等を示す。]
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)