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1. (WO2010113848) ISOTHIOUREA DERIVATIVE OR ISOUREA DERIVATIVE HAVING BACE1 INHIBITORY ACTIVITY

Pub. No.:    WO/2010/113848    International Application No.:    PCT/JP2010/055528
Publication Date: Fri Oct 08 01:59:59 CEST 2010 International Filing Date: Tue Mar 30 01:59:59 CEST 2010
IPC: C07C 275/28
A61K 31/44
A61K 31/4965
A61K 31/505
A61P 25/28
A61P 43/00
C07C 335/12
C07C 335/16
C07C 335/18
C07D 213/81
C07D 213/85
C07D 239/42
C07D 241/24
C07D 401/12
C07D 405/12
Applicants: Shionogi & Co. Ltd.
塩野義製薬株式会社
TAMURA, Yuusuke
田村 友亮
SUZUKI, Shinji
鈴木 愼司
MATSUMOTO, Sae
松本 彩枝
HORI, Akihiro
堀 章洋
KOORIYAMA, Yuuji
郡山 雄二
Inventors: TAMURA, Yuusuke
田村 友亮
SUZUKI, Shinji
鈴木 愼司
MATSUMOTO, Sae
松本 彩枝
HORI, Akihiro
堀 章洋
KOORIYAMA, Yuuji
郡山 雄二
Title: ISOTHIOUREA DERIVATIVE OR ISOUREA DERIVATIVE HAVING BACE1 INHIBITORY ACTIVITY
Abstract:
Disclosed is a compound represented by formula (I) or the like, which serves as an agent for treatment of diseases that are induced by production, secretion and/or deposition of amyloid β protein. Specifically disclosed is a compound represented by formula (I), a pharmaceutically acceptable salt thereof or a solvate thereof. (In the formula, R1 represents a substituted amino group or the like; R2 represents a halogen atom or the like; R3 represents a substituted or unsubstituted lower alkyl group or the like; RA and RB each independently represents a hydrogen atom, a substituted or unsubstituted lower alkyl group or the like; RC and RD each independently represents a hydrogen atom, a substituted or unsubstituted lower alkyl group or the like, or alternatively, RC and RD combine together and form a substituted or unsubstituted carbocyclic ring together with an adjacent carbon atom; and ring A represents a heterocyclic ring or a carbocyclic ring.)