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1. (WO2010113507) DOUBLE-STRANDED MOLECULE INHIBITING THE EXPRESSION OF GPC3
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/113507    International Application No.:    PCT/JP2010/002379
Publication Date: 07.10.2010 International Filing Date: 31.03.2010
IPC:
C12N 15/113 (2010.01), A61K 31/7105 (2006.01), A61K 48/00 (2006.01), A61P 43/00 (2006.01)
Applicants: ONCOTHERAPY SCIENCE, INC. [JP/JP]; 2-1, Sakado 3-chome, Takatsu-ku, Kawasaki-shi, Kanagawa 2130012 (JP) (For All Designated States Except US).
NAKAMURA, Yusuke [JP/JP]; (JP) (For US Only).
OHSAWA, Ryuji [JP/JP]; (JP) (For US Only).
KONUMA, Akiko [JP/JP]; (JP) (For US Only)
Inventors: NAKAMURA, Yusuke; (JP).
OHSAWA, Ryuji; (JP).
KONUMA, Akiko; (JP)
Agent: SHIMIZU, Hatsushi; Kantetsu Tsukuba Bldg. 6F, 1-1-1, Oroshi-machi, Tsuchiura-shi, Ibaraki 3000847 (JP)
Priority Data:
61/211,797 02.04.2009 US
Title (EN) DOUBLE-STRANDED MOLECULE INHIBITING THE EXPRESSION OF GPC3
(FR) MOLÉCULE BICATÉNAIRE INHIBANT L'EXPRESSION DE GPC3
Abstract: front page image
(EN)The invention features an isolated double-stranded molecule inhibiting a growth of GPC3 expressing cell. The invention also features a method for treating GPC3-related disease including esophageal cancer, gastric cancer, hepatic cancer, osteosarcoma, soft tissue cancer or endometriosis by administering the double-stranded molecule against a GPC3 gene. Furthermore, the invention features products, including the double-stranded molecules and vectors encoding them, as well as compositions containing the molecules or vectors, useful in the provided methods.
(FR)L'invention concerne une molécule bicaténaire isolée inhibant la croissance d'une cellule exprimant GPC3. L'invention concerne également une méthode de traitement d'une maladie associée à GPC3, notamment un cancer œsophagique, un cancer gastrique, un cancer hépatique, un ostéosarcome, un cancer des tissus mous ou une endométriose, par administration de la molécule bicaténaire contre un gène de GPC3. En outre, l'invention concerne des produits, en particulier des molécules bicaténaires et des vecteurs les codant, ainsi que des compositions contenant les molécules ou les vecteurs, utiles dans les méthodes de l'invention.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)