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1. (WO2010113507) DOUBLE-STRANDED MOLECULE INHIBITING THE EXPRESSION OF GPC3
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2010/113507 International Application No.: PCT/JP2010/002379
Publication Date: 07.10.2010 International Filing Date: 31.03.2010
IPC:
C12N 15/113 (2010.01) ,A61K 31/7105 (2006.01) ,A61K 48/00 (2006.01) ,A61P 43/00 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
113
Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7088
Compounds having three or more nucleosides or nucleotides
7105
Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43
Drugs for specific purposes, not provided for in groups A61P1/-A61P41/108
Applicants: NAKAMURA, Yusuke[JP/JP]; JP (UsOnly)
OHSAWA, Ryuji[JP/JP]; JP (UsOnly)
KONUMA, Akiko[JP/JP]; JP (UsOnly)
ONCOTHERAPY SCIENCE, INC.[JP/JP]; 2-1, Sakado 3-chome, Takatsu-ku, Kawasaki-shi, Kanagawa 2130012, JP (AllExceptUS)
Inventors: NAKAMURA, Yusuke; JP
OHSAWA, Ryuji; JP
KONUMA, Akiko; JP
Agent: SHIMIZU, Hatsushi; Kantetsu Tsukuba Bldg. 6F, 1-1-1, Oroshi-machi, Tsuchiura-shi, Ibaraki 3000847, JP
Priority Data:
61/211,79702.04.2009US
Title (EN) DOUBLE-STRANDED MOLECULE INHIBITING THE EXPRESSION OF GPC3
(FR) MOLÉCULE BICATÉNAIRE INHIBANT L'EXPRESSION DE GPC3
Abstract:
(EN) The invention features an isolated double-stranded molecule inhibiting a growth of GPC3 expressing cell. The invention also features a method for treating GPC3-related disease including esophageal cancer, gastric cancer, hepatic cancer, osteosarcoma, soft tissue cancer or endometriosis by administering the double-stranded molecule against a GPC3 gene. Furthermore, the invention features products, including the double-stranded molecules and vectors encoding them, as well as compositions containing the molecules or vectors, useful in the provided methods.
(FR) L'invention concerne une molécule bicaténaire isolée inhibant la croissance d'une cellule exprimant GPC3. L'invention concerne également une méthode de traitement d'une maladie associée à GPC3, notamment un cancer œsophagique, un cancer gastrique, un cancer hépatique, un ostéosarcome, un cancer des tissus mous ou une endométriose, par administration de la molécule bicaténaire contre un gène de GPC3. En outre, l'invention concerne des produits, en particulier des molécules bicaténaires et des vecteurs les codant, ainsi que des compositions contenant les molécules ou les vecteurs, utiles dans les méthodes de l'invention.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)