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1. (WO2010113498) PROPHYLACTIC AND/OR THERAPEUTIC AGENT FOR ANEMIA COMPRISING TETRAHYDROQUINOLINE COMPOUND AS ACTIVE INGREDIENT

Pub. No.:    WO/2010/113498    International Application No.:    PCT/JP2010/002355
Publication Date: Fri Oct 08 01:59:59 CEST 2010 International Filing Date: Thu Apr 01 01:59:59 CEST 2010
IPC: C07D 215/22
A61K 31/4706
A61K 31/4709
A61K 31/496
A61K 31/5377
A61P 7/06
A61P 43/00
C07D 215/44
C07D 215/46
C07D 215/48
C07D 401/04
C07D 401/12
C07D 405/12
C07D 413/04
C07D 413/12
C07D 417/12
Applicants: KOWA COMPANY, LTD.
興和株式会社
ASHIKAWA, Masanori
芦川正教
TAGASHIRA, Junya
田頭潤也
KOKETSU, Akiyasu
纐纈章泰
MORIMOTO, Toshiharu
森元俊晴
KITAMURA, Takahiro
北村崇博
TAKEMURA, Syunji
竹村俊司
WATANABE, Gen
渡部玄
NISHIYAMA, Tatsuaki
西山達明
GODA, Satoshi
合田哲
YAMABI, Masaki
山火正毅
DOI, Takeshi
土肥武
ISHIWATA, Hiroyuki
石渡博之
Inventors: ASHIKAWA, Masanori
芦川正教
TAGASHIRA, Junya
田頭潤也
KOKETSU, Akiyasu
纐纈章泰
MORIMOTO, Toshiharu
森元俊晴
KITAMURA, Takahiro
北村崇博
TAKEMURA, Syunji
竹村俊司
WATANABE, Gen
渡部玄
NISHIYAMA, Tatsuaki
西山達明
GODA, Satoshi
合田哲
YAMABI, Masaki
山火正毅
DOI, Takeshi
土肥武
ISHIWATA, Hiroyuki
石渡博之
Title: PROPHYLACTIC AND/OR THERAPEUTIC AGENT FOR ANEMIA COMPRISING TETRAHYDROQUINOLINE COMPOUND AS ACTIVE INGREDIENT
Abstract:
Disclosed is a compound which has a low molecular weight and has an activity of enhancing the production of EPO and/or an activity of enhancing the production of hemoglobin. Specifically disclosed is an EPO production enhancer and/or a hemoglobin production enhancer comprising a 1-acyl-4-(substituted oxy, substituted amino, or substituted thio)-1,2,3,4-tetrahydroquinoline derivative, more specifically a tetrahydroquinoline compound represented by general formula (1) [wherein R1, R2, R2', R3 and R3' independently represent a hydrogen atom, a C1-6 alkyl group, or the like; R4, R5, R6, R7, R8, R9 and R10 independently represent a hydrogen atom, a halogen atom, a C1-6 alkyl group, or the like; A represents N-R11, a sulfur atom, or an oxygen atom; R11 represents a hydrogen atom, a C1-6 alkyl group, or the like; B represents a C6-14 aryl group, or a 5- to 10-membered heterocyclic group; and n represents an integer of 0 or 1], a salt of the tetrahydroquinoline compound, or a solvate of the tetrahydroquinoline compound or the salt.