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1. (WO2010113117) PREPARATION OF ISOLATED AGONIST ANTI-EDAR MONOCLONAL ANTIBODIES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/113117    International Application No.:    PCT/IB2010/051385
Publication Date: 07.10.2010 International Filing Date: 30.03.2010
Chapter 2 Demand Filed:    08.08.2011    
IPC:
C07K 16/28 (2006.01), A61K 39/395 (2006.01)
Applicants: EDIMER BIOTECH S.A. [CH/CH]; Chemin de l'Eglise 7 CH-1066 Epalinges (CH) (For All Designated States Except US).
UNIVERSITE DE LAUSANNE [CH/CH]; Rue du Bugnon 21 CH-1005 Lausanne (CH) (For All Designated States Except US).
SCHNEIDER, Pascal [CH/CH]; (CH) (For US Only).
DUNKEL, Nathalie [CH/CH]; (CH) (For US Only).
DEMOTZ, Stéphane [CH/CH]; (CH) (For US Only)
Inventors: SCHNEIDER, Pascal; (CH).
DUNKEL, Nathalie; (CH).
DEMOTZ, Stéphane; (CH)
Agent: KATZAROV S.A.; Rue des Epinettes 19 CH-1227 Geneva (CH)
Priority Data:
PCT/IB2009/005118 30.03.2009 IB
Title (EN) PREPARATION OF ISOLATED AGONIST ANTI-EDAR MONOCLONAL ANTIBODIES
(FR) PRÉPARATION D'ANTICORPS MONOCLONAUX ANTI-EDAR AGONISTES ISOLÉS
Abstract: front page image
(EN)The present invention concerns the preparation of substantially purified agonist anti- EDAR monoclonal antibodies or isolated monoclonal antibody fragments or antigen binding portions or fragments thereof. The invention further relates to isolated agonist anti- EDAR monoclonal antibodies or isolated monoclonal antibody fragments or antigen binding portions or fragments thereof as well as their use in the treatment of X-lmked hypohidrotic ectodermal dysplasia and tooth agenesis. The invention also relates to a pharmaceutical composition comprising said isolated agonist anti-EDAR monoclonal antibodies or isolated monoclonal antibody fragments or antigen binding portions or fragments thereof and to a method of treating X-linked hypohidrotic ectodermal dysplasia and tooth agenesis. Finally, the present invention concerns a pharmaceutical kit comprising said isolated agonist anti-EDAR monoclonal antibodies or isolated monoclonal antibody fragments or antigen binding portions or fragments thereof.
(FR)La présente invention concerne la préparation d'anticorps monoclonaux anti-EDAR agonistes sensiblement purifiés ou de fragments desdits anticorps monoclonaux ou de parties liant l'antigène desdits anticorps monoclonaux ou de fragments de celles-ci, tous isolés. L'invention concerne en outre des anticorps monoclonaux anti-EDAR agonistes isolés, ou des fragments desdits anticorps monoclonaux ou des parties liant l'antigène desdits anticorps monoclonaux ou des fragments de celles-ci, tous isolés, ainsi que leur utilisation dans le traitement de la dysplasie ectodermique hypohidrotique liée à l'X et de l'agénésie dentaire. L'invention concerne également une composition pharmaceutique comprenant lesdits anticorps monoclonaux anti-EDAR agonistes isolés, ou fragments desdits anticorps monoclonaux ou parties liant l'antigène desdits anticorps monoclonaux ou fragments de celles-ci, tous isolés, ainsi qu'une méthode de traitement de la dysplasie ectodermique hypohidrotique liée à l'X et de l'agénésie dentaire. Enfin, la présente invention concerne une trousse pharmaceutique comprenant lesdits anticorps monoclonaux anti-EDAR agonistes isolés, ou fragments desdits anticorps monoclonaux ou parties liant l'antigène desdits anticorps monoclonaux ou fragments de celles-ci, tous isolés.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)