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1. (WO2010113096) METHODS OF PREDICTING CLINICAL COURSE AND TREATING MULTIPLE SCLEROSIS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2010/113096 International Application No.: PCT/IB2010/051344
Publication Date: 07.10.2010 International Filing Date: 28.03.2010
IPC:
C12Q 1/68 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
Applicants: ACHIRON, Anat[IL/IL]; IL (UsOnly)
GUREVICH, Michael[IL/IL]; IL (UsOnly)
TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD.[IL/IL]; The Chaim Sheba Medical Center Tel HaShomer 52621 Ramat-Gan, IL (AllExceptUS)
Inventors: ACHIRON, Anat; IL
GUREVICH, Michael; IL
Agent: G.E. EHRLICH (1995) LTD.; 11 Menachem Begin Street 52521 Ramat Gan, IL
Priority Data:
61/202,70330.03.2009US
Title (EN) METHODS OF PREDICTING CLINICAL COURSE AND TREATING MULTIPLE SCLEROSIS
(FR) MÉTHODES POUR PRÉVOIR L'ÉVOLUTION CLINIQUE DE LA SCLÉROSE EN PLAQUE ET LA TRAITER
Abstract:
(EN) Provided are methods and kits for classifying a subject as being more likely to have benign multiple sclerosis (BMS) or as being more likely to have typical relapsing remitting multiple sclerosis (RRMS). Classification of multiple sclerosis disease course is performed by comparing a level of expression of at least one gene involved in the RNA polymerase I pathway in a cell of the subject to a reference expression data of said at least one gene obtained from a cell of at least one subject pre-diagnosed as having BMS and/or from a cell of at least one subject pre-diagnosed as having typical RRMS, thereby classifying the subject as being more likely to have BMS or as being more likely to have typical RRMS. Also provided are methods of diagnosing and treating multiple sclerosis and methods of monitoring treatment efficiency.
(FR) L'invention concerne des procédés et des nécessaires pour la classification d'un sujet selon qu'il est plus susceptible d'être atteint d'une sclérose en plaques bénigne (SEPB) ou plus susceptible d'être atteint d'une sclérose en plaques récurrente-rémittente (SEPRR) typique. La classification de l'évolution de la maladie de la sclérose en plaques est réalisée en comparant un niveau d'expression d'au moins un gène impliqué dans la voie de l'ARN polymérase I dans une cellule du sujet à un résultat d'expression de référence dudit au moins un gène obtenu à partir d'une cellule d'au moins un sujet chez lequel on a préalablement diagnostiqué une SEPB et/ou d'une cellule d'au moins un sujet chez lequel on a préalablement diagnostiqué une SEPRR typique, en classant ainsi le sujet comme étant plus susceptible d'être atteint d'une SEPB ou plus susceptible d'être atteint d'une SEPRR typique. L'invention concerne également des méthodes de diagnostic et de traitement de la sclérose en plaques et des méthodes de suivi de l'efficacité du traitement.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)