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1. (WO2010113042) ANTIMICROBIAL CYCLIC PEPTIDES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/113042    International Application No.:    PCT/IB2010/001250
Publication Date: 07.10.2010 International Filing Date: 06.04.2010
IPC:
G01N 33/94 (2006.01), A61K 38/04 (2006.01), C07K 7/66 (2006.01)
Applicants: UNIVERSITEIT LEIDEN [NL/NL]; Rapenburg 70 NL-2311 EZ Leiden (NL) (For All Designated States Except US).
NEDERLANDSE ORGANISATIE VOOR TOEGEPAST- NATUURWETENSCHAPPELIJK ONDERZOEK TNO [NL/NL]; Schoemakerstraat 97 NL-2628 VK Delft (NL) (For All Designated States Except US).
RIJKSINSTITUUT VOOR VOLKSGEZONDHEID EN MILIEU [NL/NL]; Antonie van Leeuwenhoeklaan 9 NL- 3721 MA Bilthoven (NL) (For All Designated States Except US).
OVERHAND, Mark [NL/NL]; (NL) (For US Only).
KAPOERCHAN, Vanita, Varsha [NL/NL]; (NL) (For US Only).
VAN DER MAREL, Gijsbert, Arie [NL/NL]; (NL) (For US Only).
OVERKLEEFT, Herman, Steven [NL/NL]; (NL) (For US Only).
DE NEELING, Albert, Johannes [NL/NL]; (NL) (For US Only).
NOORT, Daniel [NL/NL]; (NL) (For US Only).
KNIJNENBURG, Annemiek, Dorien [NL/NL]; (NL) (For US Only)
Inventors: OVERHAND, Mark; (NL).
KAPOERCHAN, Vanita, Varsha; (NL).
VAN DER MAREL, Gijsbert, Arie; (NL).
OVERKLEEFT, Herman, Steven; (NL).
DE NEELING, Albert, Johannes; (NL).
NOORT, Daniel; (NL).
KNIJNENBURG, Annemiek, Dorien; (NL)
Agent: CHAPMAN, Paul; Marks & Clerk LLP Aurora 120 Bothwell Street Glasgow G2 7JS (GB)
Priority Data:
0905821.5 03.04.2009 GB
Title (EN) ANTIMICROBIAL CYCLIC PEPTIDES
(FR) PEPTIDES CYCLIQUES ANTIMICROBIENS
Abstract: front page image
(EN)The present invention relates to antimicrobial cyclic peptides, which display a reduced hemolytic activity and optionally antimicrobial activity in comparison to parent antimicrobial cyclic peptides from which they are derived. In one embodiment the parent cyclic peptide is gramicidin S. There is also provided a method of providing novel derivative antimicrobial cyclic peptides which have been developed from a parent antimicrobial cyclic peptide and which display a reduced haemolytic activity and/or antimicrobial activity compared to the parent molecule from which they are derived.
(FR)La présente invention concerne des peptides cycliques antimicrobiens, qui présentent une activité hémolytique réduite et éventuellement une activité antimicrobienne comparativement aux peptides cycliques antimicrobiens parents dont ils dérivent. Selon un mode de réalisation, le peptide cyclique parent est la gramicidine S. L'invention concerne également un procédé permettant d'obtenir de nouveaux peptides cycliques antimicrobiens dérivés, qui ont été développés à partir d'un peptide cyclique antimicrobien parent et qui présentent une activité hémolytique réduite et/ou une activité antimicrobienne comparativement à la molécule parente dont ils dérivent.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)