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1. (WO2010112749) SOLID LIPID NANOPARTICLES ENCAPSULATING MINOXIDIL, AND AQUEOUS SUSPENSION CONTAINING SAME
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2010/112749 International Application No.: PCT/FR2010/050574
Publication Date: 07.10.2010 International Filing Date: 29.03.2010
IPC:
A61K 9/51 (2006.01) ,A61K 31/506 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
48
Preparations in capsules, e.g. of gelatin, of chocolate
50
Microcapsules
51
Nanocapsules
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
506
not condensed and containing further heterocyclic rings
Applicants: PADOIS, Karine[FR/FR]; FR (UsOnly)
PIROT, Fabrice[FR/FR]; FR (UsOnly)
FALSON, Françoise[FR/FR]; FR (UsOnly)
UNIVERSITE CLAUDE BERNARD LYON I[FR/FR]; 43 Boulevard du 11 Novembre 1918 F-69622 Villeurbanne Cedex, FR (AllExceptUS)
Inventors: PADOIS, Karine; FR
PIROT, Fabrice; FR
FALSON, Françoise; FR
Agent: SARLIN, Laure; CABINET BEAU DE LOMENIE 51 Avenue Jean Jaures BP7073 F-69301 Lyon Cedex 07, FR
Priority Data:
095205931.03.2009FR
Title (EN) SOLID LIPID NANOPARTICLES ENCAPSULATING MINOXIDIL, AND AQUEOUS SUSPENSION CONTAINING SAME
(FR) NANOPARTICULES LIPIDIQUES SOLIDES ENCAPSULANT DU MINOXIDIL ET SUSPENSION AQUEUSE LES CONTENANT
Abstract:
(EN) The present invention relates to a suspension of solid lipid nanoparticles in an aqueous phase wherein: the solid lipid nanoparticles encapsulate minoxidil in a lipid matrix, and further include at least one amphiphilic compound A1 selected from phospholipids, and in particular from phosphatidylcholines and lecithins, propylene glycol, one or more surfactants and optionally ethanol, the aqueous phase containing water, propylene glycol and optionally ethanol. The invention also relates to the corresponding nanoparticles, to a method for producing same, as well as to cosmetic and pharmaceutical compositions containing same.
(FR) La présente invention concerne une suspension de nanoparticules lipidiques solides dans une phase aqueuse dans laquelle : les nanoparticules lipidiques solides encapsulent du minoxidil dans une matrice lipidique, et comprennent, en outre, au moins un composé amphiphile A1 choisi parmi les phospholipides, et en particulier parmi les phosphatidylcholines et les lécithines, du propylène glycol, un ou plusieurs surfactants et éventuellement de l'éthanol, la phase aqueuse contient de l'eau, du propylène glycol et éventuellement de l'éthanol. les nanoparticules correspondantes, leur procédé de préparation, ainsi que les compositions cosmétiques et pharmaceutiques les contenant.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: French (FR)
Filing Language: French (FR)