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1. (WO2010112556) POLYPEPTIDES AND USE THEREOF FOR TREATMENT OF TRAUMATIC OR DEGENERATIVE NEURONAL INJURY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/112556    International Application No.:    PCT/EP2010/054335
Publication Date: 07.10.2010 International Filing Date: 31.03.2010
IPC:
C07K 14/33 (2006.01), A61K 38/16 (2006.01)
Applicants: CHARITÉ - UNIVERSITÄTSMEDIZIN BERLIN [DE/DE]; Charitéplatz 1 10117 Berlin (DE) (For All Designated States Except US).
MEDIZINISCHE HOCHSCHULE HANNOVER [DE/DE]; Carl-Neuberg-Str. 1 30625 Hannover (DE) (For All Designated States Except US).
AHNERT-HILGER, Gudrun [DE/DE]; (DE) (For US Only).
GROßE, Gisela [DE/DE]; (DE) (For US Only).
HOFMANN, Fred [DE/DE]; (DE) (For US Only).
JUST, Ingo [DE/DE]; (DE) (For US Only).
HÖLTJE, Markus [DE/DE]; (DE) (For US Only).
HÜLSENBECK, Stefanie [DE/DE]; (DE) (For US Only)
Inventors: AHNERT-HILGER, Gudrun; (DE).
GROßE, Gisela; (DE).
HOFMANN, Fred; (DE).
JUST, Ingo; (DE).
HÖLTJE, Markus; (DE).
HÜLSENBECK, Stefanie; (DE)
Agent: GULDE HENGELHAUPT ZIEBIG & SCHNEIDER; Wallstraße 58/59 10179 Berlin (DE)
Priority Data:
09156967.3 31.03.2009 EP
Title (EN) POLYPEPTIDES AND USE THEREOF FOR TREATMENT OF TRAUMATIC OR DEGENERATIVE NEURONAL INJURY
(FR) POLYPEPTIDES ET LEUR UTILISATION POUR TRAITER UNE LÉSION NEURONALE D'ORIGINE TRAUMATIQUE OU DÉGÉNÉRATIVE
Abstract: front page image
(EN)The present invention relates to polypeptides transiently activating Ras homolog gene family member A (RhoA) GTPase, polynucleotides encoding said polypeptides and pharmaceutical compositions comprising said polypeptides or said polynucleotides. The present invention further relates to the use of said polypeptides, said polynucleotides or said pharmaceutical compositions for long-term treatment of damage of the peripheral or central nervous system.
(FR)Cette invention concerne des polypeptides qui activent transitoirement la GTPase RhoA (famille de gènes de Ras, membre homologue A), des polynucléotides codant pour lesdits polypeptides et des compositions pharmaceutiques comprenant lesdits polypeptides ou lesdits polynucléotides. La présente invention concerne, en outre, l'utilisation desdits polypeptides, desdits polynucléotides ou desdites compositions pharmaceutiques pour le traitement à long terme d'une lésion du système nerveux périphérique ou central.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)