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1. (WO2010112437) 1-HETEROCYCLYL-1, 5-DIHYDRO-PYRAZOLO [3, 4-D] PYRIMIDIN-4-ONE DERIVATIVES AND THEIR USE AS PDE9A MODULATORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/112437    International Application No.:    PCT/EP2010/054050
Publication Date: 07.10.2010 International Filing Date: 26.03.2010
IPC:
C07D 487/04 (2006.01), A61K 31/519 (2006.01)
Applicants: BOEHRINGER INGELHEIM INTERNATIONAL GMBH [DE/DE]; Binger Straße 173 55216 Ingelheim Am Rhein (DE) (For All Designated States Except US).
GIOVANNINI, Riccardo [IT/IT]; (DE) (For US Only).
DORNER-CIOSSEK, Cornelia [DE/DE]; (DE) (For US Only).
EICKMEIER, Christian [DE/DE]; (DE) (For US Only).
FIEGEN, Dennis [DE/DE]; (DE) (For US Only).
FOX, Thomas [DE/DE]; (DE) (For US Only).
FUCHS, Klaus [DE/DE]; (DE) (For US Only).
HEINE, Niklas [DE/DE]; (DE) (For US Only).
ROSENBROCK, Holger [DE/DE]; (DE) (For US Only).
SCHAENZLE, Gerhard [DE/DE]; (DE) (For US Only)
Inventors: GIOVANNINI, Riccardo; (DE).
DORNER-CIOSSEK, Cornelia; (DE).
EICKMEIER, Christian; (DE).
FIEGEN, Dennis; (DE).
FOX, Thomas; (DE).
FUCHS, Klaus; (DE).
HEINE, Niklas; (DE).
ROSENBROCK, Holger; (DE).
SCHAENZLE, Gerhard; (DE)
Agent: HAMMANN, ET.AL., Heinz; Binger Str. 173 55216 Ingelheim Am Rhein (DE)
Priority Data:
2009-000574 31.03.2009 VE
PCT/EP2009/053907 01.04.2009 EP
09171906.2 30.09.2009 EP
Title (EN) 1-HETEROCYCLYL-1, 5-DIHYDRO-PYRAZOLO [3, 4-D] PYRIMIDIN-4-ONE DERIVATIVES AND THEIR USE AS PDE9A MODULATORS
(FR) DÉRIVÉS 1-HÉTÉROCYCLYL-1, 5-DIHYDRO-PYRAZOLO [3, 4-D] PYRIMIDIN-4-ONE ET LEUR UTILISATION EN TANT QUE MODULATEURS DE PDE9A
Abstract: front page image
(EN)The invention relates to novel 1,6-disubstituted pyrazolopyrimidinones of formula (I), in which Hc is a tetrahydropyranyl-group and R1 is the group V-W-*, whereby V and W independently of each other may be an aryl group or an heteroaryl group, which independently of each other may optionally be substituted. According to one aspect of the invention the new compounds are for use as medicaments or for the manufacture of medicaments, in particular medicaments for the treatment of conditions concerning deficits in perception, concentration, learning or memory. The new compounds are also for the manufacture of medicaments and / or for use in the treatment of e.g. Alzheimer's disease, in particular for cognitive impairment associated with Alzheimer's disease.
(FR)L'invention porte sur de nouveaux pyrazolopyrimidinones 1,6-disubstitués de formule (I) dans laquelle Hc est un groupe tétrahydropyranyle et R1 est le groupe V-W-*, où V et W peuvent indépendamment être un groupe aryle ou un groupe hétéroaryle qui peuvent indépendamment être facultativement substitués. Selon un aspect de l'invention, les nouveaux composés sont destinés à être utilisés en tant que médicaments ou pour la fabrication de médicaments, en particulier de médicaments pour le traitement d'états pathologiques concernant des déficits de perception, de concentration, d'apprentissage ou de mémoire. Les nouveaux composés sont également destinés à la fabrication de médicaments et/ou destinés à une utilisation dans le traitement de, par exemple, la maladie d'Alzheimer, en particulier de dysfonctionnements cognitifs associés à la maladie d'Alzheimer.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)