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1. (WO2010112033) METHOD FOR ESTIMATING THE RISK OF HAVING OR DEVELOPING MULTIPLE SCLEROSIS USING SEQUENCE POLYMORPHISMS IN A SPECIFIC REGION OF CHROMOSOME X
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/112033    International Application No.:    PCT/DK2010/050074
Publication Date: 07.10.2010 International Filing Date: 31.03.2010
IPC:
C12Q 1/68 (2006.01), C07K 16/10 (2006.01)
Applicants: ØSTJYSK INNOVATION A/S [DK/DK]; Gustav Wieds Vej 10 DK-8000 Aarhus C (DK) (For All Designated States Except US).
ANDERSEN NEXØ, Bjørn [DK/DK]; (DK) (For US Only).
SKOU PEDERSEN, Finn [DK/DK]; (DK) (For US Only).
CHRISTENSEN, Tove [DK/DK]; (DK) (For US Only).
MØLLER LARSEN, Anné [DK/DK]; (DK) (For US Only).
VILLESEN FREDSTED, Palle [DK/DK]; (DK) (For US Only).
LASKA, Magdalena, Janina [DK/DK]; (DK) (For US Only)
Inventors: ANDERSEN NEXØ, Bjørn; (DK).
SKOU PEDERSEN, Finn; (DK).
CHRISTENSEN, Tove; (DK).
MØLLER LARSEN, Anné; (DK).
VILLESEN FREDSTED, Palle; (DK).
LASKA, Magdalena, Janina; (DK)
Agent: HØIBERG A/S; St. Kongensgade 59 A DK-1264 Copenhagen K (DK)
Priority Data:
PA 2009 00437 31.03.2009 DK
Title (EN) METHOD FOR ESTIMATING THE RISK OF HAVING OR DEVELOPING MULTIPLE SCLEROSIS USING SEQUENCE POLYMORPHISMS IN A SPECIFIC REGION OF CHROMOSOME X
(FR) MÉTHODE PERMETTANT D'ESTIMER LE RISQUE D'AVOIR OU DE DÉVELOPPER UNE SCLÉROSE EN PLAQUES À L'AIDE DE POLYMORPHISMES DE SÉQUENCE DANS UNE RÉGION PARTICULIÈRE DU CHROMOSOME X
Abstract: front page image
(EN)The present invention provides methods for identifying human subjects with an increased risk of having or developing multiple sclerosis, as well as for estimating the prognosis for multiple sclerosis of an individual and for estimating a treatment response of an individual suffering or at risk of suffering from multiple sclerosis. In particular, this invention relates to the identification and characterization of polymorphisms positioned in or near human endogenous retroviruses on the human chromosome X, 3, 6, 16 and 19. The invention also discloses use of anti-viral compounds in the combat of multiple sclerosis.
(FR)La présente invention concerne des méthodes permettant d'identifier des sujets humains présentant un risque accru d'avoir ou de développer une sclérose en plaques, ainsi que d'évaluer le pronostic d'une sclérose en plaques chez un individu et d'estimer la réponse à un traitement chez un individu souffrant ou exposé au risque de souffrir d'une sclérose en plaques. Cette invention concerne en particulier l'identification et la caractérisation de polymorphismes situés dans ou à proximité de rétrovirus endogènes humains sur les chromosomes X, 3, 6, 16 et 19 humains. Cette invention concerne également l'utilisation de composés antiviraux dans la lutte contre la sclérose en plaques.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)