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1. WO2010106016 - PYRIMIDINE DERIVATIVES USED AS ITK INHIBITORS

Publication Number WO/2010/106016
Publication Date 23.09.2010
International Application No. PCT/EP2010/053289
International Filing Date 15.03.2010
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
417
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
417
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
513
Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/, C07D477/232
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
04
Nitro compounds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11
Drugs for disorders of the respiratory system
06
Antiasthmatics
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29
Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37
Drugs for immunological or allergic disorders
C07D 417/12 (2006.01)
C07D 417/14 (2006.01)
C07D 513/04 (2006.01)
A61K 31/04 (2006.01)
A61P 11/06 (2006.01)
A61P 29/00 (2006.01)
CPC
C07D 417/12
C07D 417/14
C07D 513/04
Applicants
  • GLAXO GROUP LIMITED [GB/GB]; Glaxo Wellcome House Berkeley Avenue Greenford Middlesex UB6 0NN, GB (AllExceptUS)
  • ALDER, Catherine, Mary [GB/GB]; GB (UsOnly)
  • BALDWIN, Ian, Robert [GB/GB]; GB (UsOnly)
  • BARTON, Nicholas, Paul [GB/GB]; GB (UsOnly)
  • CAMPBELL, Amanda, Jennifer [GB/GB]; GB (UsOnly)
  • CHAMPIGNY, Aurelie, Cecile [FR/GB]; GB (UsOnly)
  • HARLING, John, David [GB/GB]; GB (UsOnly)
  • MAXWELL, Aoife, Caitriona [IE/GB]; GB (UsOnly)
  • SIMPSON, Juliet, Kay [GB/GB]; GB (UsOnly)
  • SMITH, Ian, Edward, David [GB/GB]; GB (UsOnly)
  • TAME, Christopher, John [GB/GB]; GB (UsOnly)
  • WILSON, Caroline [GB/GB]; GB (UsOnly)
  • WOOLVEN, James, Michael [GB/GB]; GB (UsOnly)
Inventors
  • ALDER, Catherine, Mary; GB
  • BALDWIN, Ian, Robert; GB
  • BARTON, Nicholas, Paul; GB
  • CAMPBELL, Amanda, Jennifer; GB
  • CHAMPIGNY, Aurelie, Cecile; GB
  • HARLING, John, David; GB
  • MAXWELL, Aoife, Caitriona; GB
  • SIMPSON, Juliet, Kay; GB
  • SMITH, Ian, Edward, David; GB
  • TAME, Christopher, John; GB
  • WILSON, Caroline; GB
  • WOOLVEN, James, Michael; GB
Agents
  • GLADWIN, Amanda, Rachel; GlaxoSmithKline Global Patents CN925.1 980 Great West Road Brentford Middlesex TW8 9GS, GB
Priority Data
61/160,89817.03.2009US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PYRIMIDINE DERIVATIVES USED AS ITK INHIBITORS
(FR) DÉRIVÉS DE PYRIMIDINE UTILISÉS COMME INHIBITEURS DE LTK
Abstract
(EN)
The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular ltk activity.
(FR)
L'invention concerne certains nouveaux composés. Spécifiquement, elle concerne des composés de formule (I) : et leurs sels. Les composés de l'invention sont des inhibiteurs d'activité kinase, en particulier d'activité ltk.
Latest bibliographic data on file with the International Bureau