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1. WO2010100405 - TRIAZINE DERIVATIVES AS KINASE INHIBITORS

Publication Number WO/2010/100405
Publication Date 10.09.2010
International Application No. PCT/GB2010/000361
International Filing Date 02.03.2010
IPC
C07D 401/14 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14containing three or more hetero rings
A61K 31/47 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
47Quinolines; Isoquinolines
A61P 9/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
CPC
A61K 31/47
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
47Quinolines; Isoquinolines
A61P 1/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
A61P 11/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
06Antiasthmatics
A61P 17/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
06Antipsoriatics
A61P 19/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
02for joint disorders, e.g. arthritis, arthrosis
A61P 25/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
08Antiepileptics; Anticonvulsants
Applicants
  • UCB PHARMA S.A. [BE]/[BE] (AllExceptUS)
  • ALLEN, Daniel, Rees [GB]/[GB] (UsOnly)
  • BÜRLI, Roland [CH]/[GB] (UsOnly)
  • HAUGHAN, Alan, Findlay [GB]/[GB] (UsOnly)
  • MACDONALD, Jonathan, David [GB]/[GB] (UsOnly)
  • MATTEUCCI, Mizio [IT]/[GB] (UsOnly)
  • NASH, David, John [GB]/[GB] (UsOnly)
  • OWENS, Andrew, Pate [GB]/[GB] (UsOnly)
  • RAPHY, Gilles [GB]/[GB] (UsOnly)
  • SAVILLE-STONES, Elizabeth, Anne [GB]/[GB] (UsOnly)
  • SHARPE, Andrew [GB]/[GB] (UsOnly)
Inventors
  • ALLEN, Daniel, Rees
  • BÜRLI, Roland
  • HAUGHAN, Alan, Findlay
  • MACDONALD, Jonathan, David
  • MATTEUCCI, Mizio
  • NASH, David, John
  • OWENS, Andrew, Pate
  • RAPHY, Gilles
  • SAVILLE-STONES, Elizabeth, Anne
  • SHARPE, Andrew
Agents
  • THOMPSON, John
Priority Data
0903949.606.03.2009GB
0915586.207.09.2009GB
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) TRIAZINE DERIVATIVES AS KINASE INHIBITORS
(FR) DÉRIVÉS DE TRIAZINE EN TANT QU'INHIBITEURS DE KINASES
Abstract
(EN) A series of substituted [1,3,5]triazin-2-yl derivatives, being selective inhibitors of PI3 kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions.
(FR) La présente invention porte sur une série de dérivés de [1,3,5]triazine-2-yliques substitués, lesquels sont des inhibiteurs sélectifs d'enzymes PI3 kinases et sont par conséquent utiles en médecine, par exemple pour le traitement d'affections inflammatoires, auto-immunes, cardiovasculaires, neurodégénératives, métaboliques, oncologiques, nociceptives ou ophtalmiques.
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