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1. WO2010100405 - TRIAZINE DERIVATIVES AS KINASE INHIBITORS

Publication Number WO/2010/100405
Publication Date 10.09.2010
International Application No. PCT/GB2010/000361
International Filing Date 02.03.2010
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14
containing three or more hetero rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
47
Quinolines; Isoquinolines
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
C07D 401/14 (2006.01)
A61K 31/47 (2006.01)
A61P 9/00 (2006.01)
CPC
A61K 31/47
C07D 401/14
Applicants
  • UCB PHARMA S.A. [BE/BE]; 60 Allée de la Recherche B-1070 Brussels, BE (AllExceptUS)
  • ALLEN, Daniel, Rees [GB/GB]; GB (UsOnly)
  • BÜRLI, Roland [CH/GB]; GB (UsOnly)
  • HAUGHAN, Alan, Findlay [GB/GB]; GB (UsOnly)
  • MACDONALD, Jonathan, David [GB/GB]; GB (UsOnly)
  • MATTEUCCI, Mizio [IT/GB]; GB (UsOnly)
  • NASH, David, John [GB/GB]; GB (UsOnly)
  • OWENS, Andrew, Pate [GB/GB]; GB (UsOnly)
  • RAPHY, Gilles [GB/GB]; GB (UsOnly)
  • SAVILLE-STONES, Elizabeth, Anne [GB/GB]; GB (UsOnly)
  • SHARPE, Andrew [GB/GB]; GB (UsOnly)
Inventors
  • ALLEN, Daniel, Rees; GB
  • BÜRLI, Roland; GB
  • HAUGHAN, Alan, Findlay; GB
  • MACDONALD, Jonathan, David; GB
  • MATTEUCCI, Mizio; GB
  • NASH, David, John; GB
  • OWENS, Andrew, Pate; GB
  • RAPHY, Gilles; GB
  • SAVILLE-STONES, Elizabeth, Anne; GB
  • SHARPE, Andrew; GB
Agents
  • THOMPSON, John; UCB Celltech 208 Bath Road Slough Berkshire SL1 3WE, GB
Priority Data
0903949.606.03.2009GB
0915586.207.09.2009GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) TRIAZINE DERIVATIVES AS KINASE INHIBITORS
(FR) DÉRIVÉS DE TRIAZINE EN TANT QU'INHIBITEURS DE KINASES
Abstract
(EN)
A series of substituted [1,3,5]triazin-2-yl derivatives, being selective inhibitors of PI3 kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions.
(FR)
La présente invention porte sur une série de dérivés de [1,3,5]triazine-2-yliques substitués, lesquels sont des inhibiteurs sélectifs d'enzymes PI3 kinases et sont par conséquent utiles en médecine, par exemple pour le traitement d'affections inflammatoires, auto-immunes, cardiovasculaires, neurodégénératives, métaboliques, oncologiques, nociceptives ou ophtalmiques.
Also published as
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