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1. (WO2010096888) VACCINES CONTAINING ATTENUATED STRAINS, METHOD FOR FORMING ATTENUATED STRAINS, VACCINE VECTORS AND USE THEREOF FOR THE TREATMENT OF SALMONELLOSIS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/096888 International Application No.: PCT/BR2010/000056
Publication Date: 02.09.2010 International Filing Date: 25.02.2010
IPC:
A61K 39/112 (2006.01) ,A61P 31/04 (2006.01) ,C12N 15/09 (2006.01) ,A61K 39/02 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
02
Bacterial antigens
112
Salmonella; Shigella
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04
Antibacterial agents
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
02
Bacterial antigens
Applicants:
UNIVERSIDADE ESTADUAL DE CAMPINAS-UNICAMP [BR/BR]; Av. Roxo Moreira, 1831 CEP 13083-970- Campinas, SP, BR (AllExceptUS)
BROCCHI, Marcelo [BR/BR]; BR (UsOnly)
MARTINES TEIXEIRA MENDES, Guilherme [BR/BR]; BR (UsOnly)
DIAS DA SILVEIRA, Wanderley [BR/BR]; BR (UsOnly)
TRINDADE MARANHÃO COSTA, Fábio [BR/BR]; BR (UsOnly)
Inventors:
BROCCHI, Marcelo; BR
MARTINES TEIXEIRA MENDES, Guilherme; BR
DIAS DA SILVEIRA, Wanderley; BR
TRINDADE MARANHÃO COSTA, Fábio; BR
Agent:
SILVADO, FERNANDA LAVRAS COSTALLAT; Rua Roxo Moreira 1631 Caixa Postal 6131 CEP 13083-970 Campinas, SP, BR
Priority Data:
PI0902944-327.02.2009BR
Title (EN) VACCINES CONTAINING ATTENUATED STRAINS, METHOD FOR FORMING ATTENUATED STRAINS, VACCINE VECTORS AND USE THEREOF FOR THE TREATMENT OF SALMONELLOSIS
(FR) VACCINS COMPRENANT DES SOUCHES ATTÉNUÉES, PROCÉDÉ DE CONSTRUCTION DE SOUCHES ATTÉNUÉES, VECTEURS VACCINAUX ET LEUR UTILISATION DANS LE TRAITEMENT DE LA SALMONELLOSE
(PT) VACINAS COMPREENDENDO LINHAGENS ATENUADAS, PROCESSO DE CONSTRUÇÃO DE LINHAGENS ATENUADAS, VETORES VACINAIS E SEU USO NO TRATAMENTO DA SALMONELOSE
Abstract:
(EN) The present invention discloses a new alternative for the prevention of salmonellosis, using mutants that can promote immunisation in the host. In particular, these mutants are neutral for the IHF himA and himD genes, and were tested for virulence attenuation and capacity to trigger an effective immune response that protects against salmonellosis, in particular against murine salmonellosis. Consequently, the present invention is directed to a method for producing this attenuated mutant strain capable of promoting immunisation, to vaccine vectors and vaccines for the treatment of salmonellosis, and to the use thereof for combatting said infection.
(FR) La présente invention concerne une nouvelle alternative pour la prévention de la salmonellose, au moyen de mutants pouvant promouvoir l'immunisation de l'hôte. Plus particulièrement, ces mutants sont nuls pour les gènes himA et himD d'IHF et ont été testés en termes d'atténuation de la virulence et de capacité de déclenchement d'une réponse immunitaire efficace et protectrice contre la salmonellose, notamment contre la salmonellose murine. Ainsi, la présente invention concerne un procédé de production de cette souche de mutants atténués pouvant promouvoir l'immunisation, des vecteurs vaccinaux et des vaccins pour le traitement de la salmonellose ainsi que leur utilisation pour combattre ladite infection.
(PT) A presente invenção revela uma nova alternativa para a prevenção de salmonelose, a partir de mutantes capazes de promover imunização do hospedeiro. Em especial tais mutantes são nulos para os genes himA e himD de IHF e foram testados quanto a atenuação da virulência e capacidade de desencadear resposta imune efetiva e protetora contra a salmonelose, em especial a salmonelose murina. Logo, a presente invenção está destinada a um processo de produção desta linhagem de mutantes atenuados, capazes de promover imunização, a vetores vacinais e vacinas para o tratamento de salmonelose e a seu uso no combate a tal infecção.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: Portuguese (PT)
Filing Language: Portuguese (PT)