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1. (WO2010096696) HARNESSING HIGH THROUGHPUT SEQUENCING FOR MULTIPLEXED SPECIMEN ANALYSIS

Pub. No.:    WO/2010/096696    International Application No.:    PCT/US2010/024795
Publication Date: Fri Aug 27 01:59:59 CEST 2010 International Filing Date: Sat Feb 20 00:59:59 CET 2010
IPC: C12Q 1/68
G06F 19/18
Applicants: COLD SPRING HARBOR LABORATORY
HANNON, Gregory, J.
ERLICH, Yaniv
Inventors: HANNON, Gregory, J.
ERLICH, Yaniv
Title: HARNESSING HIGH THROUGHPUT SEQUENCING FOR MULTIPLEXED SPECIMEN ANALYSIS
Abstract:
A method of associating a DNA sequence with a specimen pooled among a plurality of specimens, where the specimens may be pooled according to any number of pooling schemes, including the Chinese Remainder Theorem, random pool selection, shifted transversal design, and Chinese Remainder Sieve. A unique identifier is associated with each specimen according to the pooling scheme such that a decoder may associate a DNA sequence with each specimen after next-generation sequencing according to the unique identifier and the chosen pooling scheme.