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1. WO2010096314 - INDOLE/BENZIMIDAZOLE COMPOUNDS AS mTOR KINASE INHIBITORS

Publication Number WO/2010/096314
Publication Date 26.08.2010
International Application No. PCT/US2010/023764
International Filing Date 10.02.2010
IPC
C07D 401/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14containing three or more hetero rings
C07D 403/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
403Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02containing two hetero rings
04directly linked by a ring-member-to-ring- member bond
C07D 403/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
403Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
14containing three or more hetero rings
C07D 405/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
405Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
14containing three or more hetero rings
C07D 409/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
409Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
14containing three or more hetero rings
C07D 413/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
413Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
14containing three or more hetero rings
CPC
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
C07D 401/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14containing three or more hetero rings
C07D 403/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
403Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
02containing two hetero rings
04directly linked by a ring-member-to-ring-member bond
C07D 403/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
403Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
14containing three or more hetero rings
C07D 405/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
405Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
14containing three or more hetero rings
Applicants
  • AMGEN INC. [US]/[US] (AllExceptUS)
  • BOEZIO, Alessandro [CA]/[US] (UsOnly)
  • CHENG, Alan, C. [US]/[US] (UsOnly)
  • COATS, James, R. [US]/[US] (UsOnly)
  • COPELAND, Katrina, W. [US]/[US] (UsOnly)
  • GRACEFFA, Russell [US]/[US] (UsOnly)
  • HARMANGE, Jean-Christophe [FR]/[US] (UsOnly)
  • HUANG, Hongbing [CN]/[US] (UsOnly)
  • LA, Daniel [US]/[US] (UsOnly)
  • OLIVIERI, Philip, R. [US]/[US] (UsOnly)
  • PETERSON, Emily, A. [US]/[US] (UsOnly)
  • SCHENKEL, Laurie [US]/[US] (UsOnly)
Inventors
  • BOEZIO, Alessandro
  • CHENG, Alan, C.
  • COATS, James, R.
  • COPELAND, Katrina, W.
  • GRACEFFA, Russell
  • HARMANGE, Jean-Christophe
  • HUANG, Hongbing
  • LA, Daniel
  • OLIVIERI, Philip, R.
  • PETERSON, Emily, A.
  • SCHENKEL, Laurie
Agents
  • BANSAL, Rekha, P.
Priority Data
61/153,58018.02.2009US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) INDOLE/BENZIMIDAZOLE COMPOUNDS AS mTOR KINASE INHIBITORS
(FR) COMPOSÉS D'INDOLE OU BENZIMIDAZOLE CONVENANT COMME INHIBITEURS DE LA KINASE MTOR
Abstract
(EN)
The present invention provides compounds that are kinase inhibitors, specifically PIK kinase inhibitors, more specifically, mTOR inhibitors and are therefore useful for the treatment of diseases treatable by inhibition of kinases, specifically PIK kinase inhibitors, more specifically, mTOR such as cancer. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.
(FR)
La présente invention concerne des composés qui sont des inhibiteurs de kinases, en particulier des inhibiteurs de kinases PIK, et plus particulièrement des inhibiteurs de mTOR, ce qui fait qu'il conviennent pour le traitement d'affections, telles que le cancer, pouvant se traiter par inhibition de kinases, en particulier au moyen d'inhibiteurs de kinases PIK, et plus particulièrement des inhibiteurs de mTOR. L'invention concerne également, d'une part des compositions pharmaceutiques contenant de tels composés, et d'autre part des procédés d'élaboration de tels composés.
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