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1. WO2010094956 - TRIAZOLOPYRIDINE DERIVATIVES AS P38 MAP KINASE INHIBITORS

Publication Number WO/2010/094956
Publication Date 26.08.2010
International Application No. PCT/GB2010/050257
International Filing Date 16.02.2010
IPC
C07D 471/04 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
A61P 11/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
A61P 29/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
A61K 31/4162 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
4151,2-Diazoles
4162condensed with heterocyclic ring systems
CPC
A61K 31/437
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
4353ortho- or peri-condensed with heterocyclic ring systems
437the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
A61P 11/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
A61P 11/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
06Antiasthmatics
A61P 29/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or anti-inflammatory agents, e.g antirheumatic agents; Non-steroidal anti-inflammatory drugs (NSAIDs)
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
C07D 413/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
413Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
Applicants
  • CHIESI FARMACEUTICI S.P.A. [IT]/[IT] (AllExceptUS)
  • FINCH, Harry [GB]/[GB] (UsOnly)
  • MONTANA, John [GB]/[GB] (UsOnly)
  • VAN NIEL, Monique Bodil [NL]/[GB] (UsOnly)
  • WOO, Chi-Kit [GB]/[GB] (UsOnly)
  • KNIGHT, Jamie [GB]/[GB] (UsOnly)
  • WASZKOWYCZ, Bohdan [GB]/[GB] (UsOnly)
Inventors
  • FINCH, Harry
  • MONTANA, John
  • VAN NIEL, Monique Bodil
  • WOO, Chi-Kit
  • KNIGHT, Jamie
  • WASZKOWYCZ, Bohdan
Agents
  • MINOJA, Fabrizio
Priority Data
0902651.917.02.2009GB
0908069.811.05.2009GB
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) TRIAZOLOPYRIDINE DERIVATIVES AS P38 MAP KINASE INHIBITORS
(FR) DÉRIVÉS DE TRIAZOLOPYRIDINE UTILISÉS COMME INHIBITEURS DE LA P38 MAP KINASE
Abstract
(EN) Compounds of formula (I) are inhibitors of p38 MAP kinase, useful as anti-inflammatory agents in the treatment of, inter alia, diseases of the respiratory tract wherein; R1 is C1-C6 alkyl, C3-C6 cycloalkyl, phenyl which is optionally substituted, 5- or 6 membered monocyclic heteroaryl which is optionally substituted, or a radical of formula (II) wherein n is 1 or 2, and R3 and R4 are independently H or C1-C6 alkyl, or R3 and R4 taken together with the nitrogen to which they are attached form a 6- membered heterocyclic ring optionally containing a further heteroatom selected from N and O; Y is -O- or -S(O)P- wherein p is 0, 1 or 2; A is an optionally substituted divalent arylene radical, or a mono- or bicyclic heteroarylene radical, or a C3-C6 divale nt cycloalkylene radical having 5 or 6 ring atoms, or a piperidinylene radical wherein the ring nitrogen is linked to R2NHC(=O)W-; W is a bond, -NH- or -C(RA)(RB), wherein RA and RB are independently H, methyl, ethyl, amino, hydroxyl or halo; and R2 is a radical as defined in the claims.
(FR) L'invention concerne des composés représentés par la formule (I) qui sont des inhibiteurs de la p38 MAP utilisés comme agents anti-inflammatoires pour traiter, inter alia, les maladies des voies respiratoires. Dans la formule (I), R1 représente alkyle C1-C6, cycloalkyle C3-C6, phényle qui est éventuellement substitué, hétéroaryle monocyclique à 5 ou 6 éléments qui est éventuellement substitué, ou un radical représenté par la formule (II) dans lequel n est égal à 1 ou 2, et R3 et R4 représentent indépendamment H ou alkyle C1-C6, ou R3 et R4 pris ensemble avec l'azote à laquelle ils sont liés forment un cycle hétérocyclique à 6 éléments contenant éventuellement un autre hétéroatome sélectionné parmi N et O; Y représente -O- ou -S(O)P- dans lequel p est égal à 0, 1 ou 2 ; A représente éventuellement un radical arylène divalent éventuellement substitué, ou un radical hétéroarylène monocyclique ou bicyclique, ou un radical cycloalkylène divalent C3-C6 comprenant 5 ou 6 atomes de cycle, ou un radical pipéridinylène dans lequel l'azote de cycle est liée à R2NHC(=O)W- ; W représente une liaison, -NH- ou -C(RA)(RB), dans lequel RA et RB représentent indépendamment H, méthyle, éthyle, amino, hydroxyle ou halo ; et R2 représente un radical tel que défini dans les revendications.
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