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1. (WO2010094956) TRIAZOLOPYRIDINE DERIVATIVES AS P38 MAP KINASE INHIBITORS
Latest bibliographic data on file with the International Bureau   
Pub. No.: WO/2010/094956 International Application No.: PCT/GB2010/050257
Publication Date: 26.08.2010 International Filing Date: 16.02.2010
IPC:
C07D 471/04 (2006.01) ,A61P 11/00 (2006.01) ,A61P 29/00 (2006.01) ,A61K 31/4162 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11
Drugs for disorders of the respiratory system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29
Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
415
1,2-Diazoles
4162
condensed with heterocyclic ring systems
Applicants:
FINCH, Harry [GB/GB]; GB (UsOnly)
MONTANA, John [GB/GB]; GB (UsOnly)
VAN NIEL, Monique Bodil [NL/GB]; GB (UsOnly)
WOO, Chi-Kit [GB/GB]; GB (UsOnly)
KNIGHT, Jamie [GB/GB]; GB (UsOnly)
WASZKOWYCZ, Bohdan [GB/GB]; GB (UsOnly)
CHIESI FARMACEUTICI S.P.A. [IT/IT]; Via Palermo, 26/A I-43100 Parma, IT (AllExceptUS)
Inventors:
FINCH, Harry; GB
MONTANA, John; GB
VAN NIEL, Monique Bodil; GB
WOO, Chi-Kit; GB
KNIGHT, Jamie; GB
WASZKOWYCZ, Bohdan; GB
Agent:
MINOJA, Fabrizio; BIANCHETTI BRACCO MINOJA S.R.L. Via Plinio, 63 I-20129 Milano, IT
Priority Data:
0902651.917.02.2009GB
0908069.811.05.2009GB
Title (EN) TRIAZOLOPYRIDINE DERIVATIVES AS P38 MAP KINASE INHIBITORS
(FR) DÉRIVÉS DE TRIAZOLOPYRIDINE UTILISÉS COMME INHIBITEURS DE LA P38 MAP KINASE
Abstract:
(EN) Compounds of formula (I) are inhibitors of p38 MAP kinase, useful as anti-inflammatory agents in the treatment of, inter alia, diseases of the respiratory tract wherein; R1 is C1-C6 alkyl, C3-C6 cycloalkyl, phenyl which is optionally substituted, 5- or 6 membered monocyclic heteroaryl which is optionally substituted, or a radical of formula (II) wherein n is 1 or 2, and R3 and R4 are independently H or C1-C6 alkyl, or R3 and R4 taken together with the nitrogen to which they are attached form a 6- membered heterocyclic ring optionally containing a further heteroatom selected from N and O; Y is -O- or -S(O)P- wherein p is 0, 1 or 2; A is an optionally substituted divalent arylene radical, or a mono- or bicyclic heteroarylene radical, or a C3-C6 divale nt cycloalkylene radical having 5 or 6 ring atoms, or a piperidinylene radical wherein the ring nitrogen is linked to R2NHC(=O)W-; W is a bond, -NH- or -C(RA)(RB), wherein RA and RB are independently H, methyl, ethyl, amino, hydroxyl or halo; and R2 is a radical as defined in the claims.
(FR) L'invention concerne des composés représentés par la formule (I) qui sont des inhibiteurs de la p38 MAP utilisés comme agents anti-inflammatoires pour traiter, inter alia, les maladies des voies respiratoires. Dans la formule (I), R1 représente alkyle C1-C6, cycloalkyle C3-C6, phényle qui est éventuellement substitué, hétéroaryle monocyclique à 5 ou 6 éléments qui est éventuellement substitué, ou un radical représenté par la formule (II) dans lequel n est égal à 1 ou 2, et R3 et R4 représentent indépendamment H ou alkyle C1-C6, ou R3 et R4 pris ensemble avec l'azote à laquelle ils sont liés forment un cycle hétérocyclique à 6 éléments contenant éventuellement un autre hétéroatome sélectionné parmi N et O; Y représente -O- ou -S(O)P- dans lequel p est égal à 0, 1 ou 2 ; A représente éventuellement un radical arylène divalent éventuellement substitué, ou un radical hétéroarylène monocyclique ou bicyclique, ou un radical cycloalkylène divalent C3-C6 comprenant 5 ou 6 atomes de cycle, ou un radical pipéridinylène dans lequel l'azote de cycle est liée à R2NHC(=O)W- ; W représente une liaison, -NH- ou -C(RA)(RB), dans lequel RA et RB représentent indépendamment H, méthyle, éthyle, amino, hydroxyle ou halo ; et R2 représente un radical tel que défini dans les revendications.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)