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1. WO2010094734 - METHODS FOR IDENTIFYING AND COMPOUNDS USEFUL FOR THE DIAGNOSIS AND TREATMENT OF DISEASES INVOLVING INFLAMMATION

Publication Number WO/2010/094734
Publication Date 26.08.2010
International Application No. PCT/EP2010/052030
International Filing Date 18.02.2010
IPC
A61K 31/7088 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7088Compounds having three or more nucleosides or nucleotides
A61K 38/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C12N 15/11 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
G01N 33/68 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
CPC
A61K 31/7088
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7088Compounds having three or more nucleosides or nucleotides
A61K 38/177
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
177Receptors; Cell surface antigens; Cell surface determinants
A61K 38/43
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
43Enzymes; Proenzymes; Derivatives thereof
A61P 1/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
A61P 11/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
06Antiasthmatics
A61P 17/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
06Antipsoriatics
Applicants
  • GALAPAGOS NV [BE]/[BE] (AllExceptUS)
  • JANSSEN, Richard, Antonius, Jozef [NL]/[NL] (UsOnly)
  • DE GROOT, Anton [NL]/[NL] (UsOnly)
  • LEKKERKERKER, Annemarie, Nicolette [NL]/[NL] (UsOnly)
  • MELDRUM, Eric, Charles [GB]/[CH] (UsOnly)
  • THOMPSON, Nicola [GB]/[GB] (UsOnly)
  • DICKSON, Marion, Catherine [GB]/[GB] (UsOnly)
  • RAY, Keith, Paul [GB]/[GB] (UsOnly)
  • BOYCE, Susan, Heather [GB]/[GB] (UsOnly)
Inventors
  • JANSSEN, Richard, Antonius, Jozef
  • DE GROOT, Anton
  • LEKKERKERKER, Annemarie, Nicolette
  • MELDRUM, Eric, Charles
  • THOMPSON, Nicola
  • DICKSON, Marion, Catherine
  • RAY, Keith, Paul
  • BOYCE, Susan, Heather
Agents
  • GOODALL, Scott
Priority Data
61/208,27119.02.2009US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) METHODS FOR IDENTIFYING AND COMPOUNDS USEFUL FOR THE DIAGNOSIS AND TREATMENT OF DISEASES INVOLVING INFLAMMATION
(FR) PROCÉDÉS D'IDENTIFICATION DE COMPOSÉS UTILES POUR LE DIAGNOSTIC ET LE TRAITEMENT DE MALADIES LIÉES À UNE INFLAMMATION
Abstract
(EN) The present invention relates to agents, and methods for identifying compounds, which agents and compounds result in the inhibition of the activation of macrophages. In addition, the invention relates to compositions and methods for the use thereof in treating conditions that are characterized by activation of macrophages including infections, allograft reactions, inflammation, allergic and autoimmune diseases, metabolic disease, cardiovascular disease, tissue injury, and cancer.
(FR) La présente invention concerne des agents et des procédés permettant d'identifier des composés, lesquels agents et composés conduisent à l'inhibition de l'activation des macrophages. En outre, l'invention concerne des compositions et leurs méthodes d'utilisation pour le traitement d'affections qui sont caractérisées par l'activation des macrophages, notamment les infections, les réactions de greffes allogéniques, l'inflammation, les maladies allergiques et auto-immunes, les maladies métaboliques, les maladies cardiovasculaires, les lésions tissulaires et le cancer.
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