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1. (WO2010094734) METHODS FOR IDENTIFYING AND COMPOUNDS USEFUL FOR THE DIAGNOSIS AND TREATMENT OF DISEASES INVOLVING INFLAMMATION
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2010/094734 International Application No.: PCT/EP2010/052030
Publication Date: 26.08.2010 International Filing Date: 18.02.2010
IPC:
A61K 31/7088 (2006.01) ,A61K 38/00 (2006.01) ,C12N 15/11 (2006.01) ,G01N 33/68 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7088
Compounds having three or more nucleosides or nucleotides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68
involving proteins, peptides or amino acids
Applicants:
JANSSEN, Richard, Antonius, Jozef [NL/NL]; NL (UsOnly)
DE GROOT, Anton [NL/NL]; NL (UsOnly)
LEKKERKERKER, Annemarie, Nicolette [NL/NL]; NL (UsOnly)
MELDRUM, Eric, Charles [GB/CH]; CH (UsOnly)
THOMPSON, Nicola [GB/GB]; GB (UsOnly)
DICKSON, Marion, Catherine [GB/GB]; GB (UsOnly)
RAY, Keith, Paul [GB/GB]; GB (UsOnly)
BOYCE, Susan, Heather [GB/GB]; GB (UsOnly)
GALAPAGOS NV [BE/BE]; Generaal De Wittelaan L11/A3 B-2800 Mechelen, BE (AllExceptUS)
Inventors:
JANSSEN, Richard, Antonius, Jozef; NL
DE GROOT, Anton; NL
LEKKERKERKER, Annemarie, Nicolette; NL
MELDRUM, Eric, Charles; CH
THOMPSON, Nicola; GB
DICKSON, Marion, Catherine; GB
RAY, Keith, Paul; GB
BOYCE, Susan, Heather; GB
Agent:
GOODALL, Scott; Sagittarius IP Taylor House 39 High Street Marlow Buckinghamshire SL7 1AF, GB
Priority Data:
61/208,27119.02.2009US
Title (EN) METHODS FOR IDENTIFYING AND COMPOUNDS USEFUL FOR THE DIAGNOSIS AND TREATMENT OF DISEASES INVOLVING INFLAMMATION
(FR) PROCÉDÉS D'IDENTIFICATION DE COMPOSÉS UTILES POUR LE DIAGNOSTIC ET LE TRAITEMENT DE MALADIES LIÉES À UNE INFLAMMATION
Abstract:
(EN) The present invention relates to agents, and methods for identifying compounds, which agents and compounds result in the inhibition of the activation of macrophages. In addition, the invention relates to compositions and methods for the use thereof in treating conditions that are characterized by activation of macrophages including infections, allograft reactions, inflammation, allergic and autoimmune diseases, metabolic disease, cardiovascular disease, tissue injury, and cancer.
(FR) La présente invention concerne des agents et des procédés permettant d'identifier des composés, lesquels agents et composés conduisent à l'inhibition de l'activation des macrophages. En outre, l'invention concerne des compositions et leurs méthodes d'utilisation pour le traitement d'affections qui sont caractérisées par l'activation des macrophages, notamment les infections, les réactions de greffes allogéniques, l'inflammation, les maladies allergiques et auto-immunes, les maladies métaboliques, les maladies cardiovasculaires, les lésions tissulaires et le cancer.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)