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1. WO2010094733 - METHODS FOR IDENTIFYING AND COMPOUNDS USEFUL FOR THE DIAGNOSIS AND TREATMENT OF DISEASES INVOLVING INFLAMMATION

Publication Number WO/2010/094733
Publication Date 26.08.2010
International Application No. PCT/EP2010/052029
International Filing Date 18.02.2010
IPC
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7088
Compounds having three or more nucleosides or nucleotides
713
Double-stranded nucleic acids or oligonucleotides
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
113
Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37
Drugs for immunological or allergic disorders
A61K 31/713 (2006.01)
G01N 33/00 (2006.01)
C12N 15/113 (2010.01)
A61P 37/00 (2006.01)
CPC
A61K 31/713
C12N 15/1136
C12N 15/1137
C12N 15/1138
C12N 2310/11
C12N 2310/14
Applicants
  • GALAPAGOS N/V [BE/BE]; Generaal De Wittelaan L11/A3 2800 Mechelen, BE (AllExceptUS)
  • JANSSEN, Richard, Antonius, Jozef [NL/NL]; NL (UsOnly)
  • DE GROOT, Anton [NL/NL]; NL (UsOnly)
  • LEKKERKERKER, Annemarie, Nicolette [NL/NL]; NL (UsOnly)
  • MELDRUM, Eric, Charles [GB/CH]; CH (UsOnly)
  • THOMPSON, Nicola [GB/GB]; GB (UsOnly)
  • FATTAH, Dilniya [GB/GB]; GB (UsOnly)
Inventors
  • JANSSEN, Richard, Antonius, Jozef; NL
  • DE GROOT, Anton; NL
  • LEKKERKERKER, Annemarie, Nicolette; NL
  • MELDRUM, Eric, Charles; CH
  • THOMPSON, Nicola; GB
  • FATTAH, Dilniya; GB
Agents
  • GOODALL, Scott; Sagittaruis IP Taylor House 39 High Street Marlow Buckinghamshire SL7 1AF, GB
Priority Data
61/208,27619.02.2009US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHODS FOR IDENTIFYING AND COMPOUNDS USEFUL FOR THE DIAGNOSIS AND TREATMENT OF DISEASES INVOLVING INFLAMMATION
(FR) PROCÉDÉS D'IDENTIFICATION DE COMPOSÉS UTILES POUR LE DIAGNOSTIC ET LE TRAITEMENT DE MALADIES LIÉES À UNE INFLAMMATION
Abstract
(EN)
The present invention relates to agents, and methods for identifying compounds, which agents and compounds result in the inhibition of the maturation of dendritic cells. In addition, the invention relates to compositions and methods for the use thereof in treating conditions that are characterized by maturation of dendritic cells including infections, allograft reactions, inflammation, allergic and autoimmune diseases, and cancer.
(FR)
La présente invention concerne des agents et des procédés permettant d'identifier des composés, lesquels agents et composés conduisent à l'inhibition de la maturation des cellules dendritiques. En outre, l'invention concerne des compositions et leurs méthodes d'utilisation pour le traitement d'affections qui sont caractérisées par la maturation des cellules dendritiques, notamment les infections, les réactions de greffes allogéniques, l'inflammation, les maladies allergiques et auto-immunes, et le cancer.
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