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1. WO2010092071 - CUSTOMIZED MOLECULARLY IMPRINTED POLYMER (MIP) UNITS

Publication Number WO/2010/092071
Publication Date 19.08.2010
International Application No. PCT/EP2010/051629
International Filing Date 10.02.2010
IPC
C08F 2/44 2006.01
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
2Processes of polymerisation
44Polymerisation in the presence of compounding ingredients, e.g. plasticisers, dyestuffs, fillers
C08F 2/06 2006.01
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
2Processes of polymerisation
04Polymerisation in solution
06Organic solvent
B01J 20/26 2006.01
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
20Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
22comprising organic material
26Synthetic macromolecular compounds
C08F 8/00 2006.01
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
8Chemical modification by after-treatment
B01D 15/38 2006.01
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
15Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
08Selective adsorption, e.g. chromatography
26characterised by the separation mechanism
38involving specific interaction not covered by one or more of groups B01D15/30-B01D15/36120
G01N 33/58 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
58involving labelled substances
CPC
B01D 15/3852
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
15Separating processes involving the treatment of liquids with solid sorbents
08Selective adsorption, e.g. chromatography
26characterised by the separation mechanism
38involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
3852using imprinted phases or molecular recognition; using imprinted phases
B01J 20/26
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
20Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
22comprising organic material
26Synthetic macromolecular compounds
B01J 20/268
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
20Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
22comprising organic material
26Synthetic macromolecular compounds
268Polymers created by use of a template, e.g. molecularly imprinted polymers
B01J 2220/54
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
2220Aspects relating to sorbent materials
50Aspects relating to the use of sorbent or filter aid materials
54Sorbents specially adapted for analytical or investigative chromatography
C08F 2/14
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
2Processes of polymerisation
12Polymerisation in non-solvents
14Organic medium
C08F 2/44
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
2Processes of polymerisation
44Polymerisation in the presence of compounding ingredients, e.g. plasticisers, dyestuffs, fillers
Applicants
  • IMEGO AKTIEBOLAG [SE]/[SE] (AllExceptUS)
  • KROZER, Anatol [SE]/[SE] (UsOnly)
  • REIMHULT, Kristina [SE]/[SE] (UsOnly)
  • LÖFVING, Björn [SE]/[SE] (UsOnly)
  • MALM, Björn [SE]/[SE] (UsOnly)
  • YE, Lei [CN]/[SE] (UsOnly)
  • YOSHIMATSU, Keiichi [JP]/[SE] (UsOnly)
Inventors
  • KROZER, Anatol
  • REIMHULT, Kristina
  • LÖFVING, Björn
  • MALM, Björn
  • YE, Lei
  • YOSHIMATSU, Keiichi
Agents
  • FRITSCHE, Daniel
Priority Data
0950083-616.02.2009SE
61/152,82716.02.2009US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) CUSTOMIZED MOLECULARLY IMPRINTED POLYMER (MIP) UNITS
(FR) UNITÉS POLYMÈRES À EMPREINTE MOLÉCULAIRE (MIP) PERSONNALISÉES
Abstract
(EN)
A method of manufacturing at least one customized MIP unit comprising: (a) providing at least one MIP unit having a surface comprising at least one target binding site configured to resemble a target molecule and surface-bound chargeable groups; (b) contacting the MIP unit(s) from the step (a) with at least one template molecule in a first solvent allowing the template molecule (s) to bind to the MIP unit(s); (c) passivating the surface-bound chargeable groups on the MIP unit(s) by adding a passivating agent; and (d) removing the template molecule (s) by washing in a second solvent, wherein the passivating agent binds to the surface of the unit(s) through bonds which remain stable upon washing in the second solvent.
(FR)
La présente invention concerne un procédé de fabrication d'au moins une unité MIP personnalisée comprenant les étapes consistant à : (a) fournir au moins une unité MIP ayant une surface comprenant au moins un site de liaison cible configuré de façon à ressembler à une molécule cible et à des groupes chargeables liés à la surface; (b) mettre en contact les unités MIP obtenues l'étape (a) avec au moins une molécule gabarit dans un premier solvant permettant à la molécule gabarit de se lier aux unités MIP; (c) passiver les groupes chargeables liés à la surface sur les unités MIP en ajoutant un agent de passivation; et (d) éliminer les molécules gabarit par lavage dans un second solvant, l'agent de passivation se liant à la surface des unités par le biais de liaisons qui restent stables après lavage dans le second solvant.
Also published as
Latest bibliographic data on file with the International Bureau