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1. WO2010091808 - FUSED PYRIMIDINES

Publication Number WO/2010/091808
Publication Date 19.08.2010
International Application No. PCT/EP2010/000620
International Filing Date 02.02.2010
IPC
C07D 487/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
A61K 31/519 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519ortho- or peri-condensed with heterocyclic rings
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
CPC
A61K 31/495
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two ; or more; nitrogen atoms as the only ring heteroatoms, e.g. piperazine ; or tetrazines
A61K 31/505
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two ; or more; nitrogen atoms as the only ring heteroatoms, e.g. piperazine ; or tetrazines
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
A61K 31/519
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two ; or more; nitrogen atoms as the only ring heteroatoms, e.g. piperazine ; or tetrazines
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519ortho- or peri-condensed with heterocyclic rings
A61K 45/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61P 1/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
04for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
A61P 1/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
16for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
Applicants
  • BAYER PHARMA AKTIENGESELLSCHAFT [DE]/[DE] (AllExceptUS)
  • VENNEMANN, Matthias [DE]/[DE] (UsOnly)
  • BÄR, Thomas [DE]/[DE] (UsOnly)
  • MAIER, Thomas [DE]/[DE] (UsOnly)
  • HÖLDER, Swen [DE]/[GB] (UsOnly)
  • BENEKE, Gerrit [DE]/[DE] (UsOnly)
  • DEHMEL, Florian [DE]/[DE] (UsOnly)
  • ZÜLCH, Armin [DE]/[DE] (UsOnly)
  • STRUB, Andreas [DE]/[DE] (UsOnly)
  • BECKERS, Thomas [NL]/[DE] (UsOnly)
  • INCE, Stuart [GB]/[DE] (UsOnly)
  • REHWINKEL, Hartmut [DE]/[DE] (UsOnly)
  • LIU, Ningshu [DE]/[DE] (UsOnly)
  • BÖMER, Ulf [DE]/[DE] (UsOnly)
Inventors
  • VENNEMANN, Matthias
  • BÄR, Thomas
  • MAIER, Thomas
  • HÖLDER, Swen
  • BENEKE, Gerrit
  • DEHMEL, Florian
  • ZÜLCH, Armin
  • STRUB, Andreas
  • BECKERS, Thomas
  • INCE, Stuart
  • REHWINKEL, Hartmut
  • LIU, Ningshu
  • BÖMER, Ulf
Common Representative
  • BAYER PHARMA AKTIENGESELLSCHAFT [DE]/[DE]
Priority Data
09075072.013.02.2009EP
09152914.916.02.2009EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) FUSED PYRIMIDINES
(FR) PYRIMIDINES CONDENSÉES
Abstract
(EN)
Compounds of formula (I), or an N-oxide, a salt, a tautomer or a stereoisomer of said compound, or a salt of said N-oxide, tautomer or stereoisomer, wherein ring B and the pyrimidine to which it is fused, R4, R5, R6, R7, m and n have the meanings as given in the description and the claims, which are effective inhibitors of the Pi3K/Akt pathway, processes for their production and their use as pharmaceuticals.
(FR)
La présente invention concerne des composés de formule (I) ou un N‑oxyde, un sel, un tautomère ou un stéréo-isomère desdits composés, ou un sel dudit N‑oxyde, tautomère ou stéréo-isomère desdits composés, où le cycle B et la pyrimidine avec laquelle il est condensé, R4, R5, R6, R7, m et n ont les significations telles que données dans la description et les revendications, qui sont des inhibiteurs efficaces de la voie Pi3K/Akt, des procédés pour leur production et leur utilisation en tant qu'agents pharmaceutiques.
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