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1. (WO2010086351) 3'-N-SUBSTITUTED 9-DEOXO-9A-METHYL-9A-AZA-HOMOERYTHROMYCIN HAVING ANTIMALARIAL ACTIVITY

Pub. No.:    WO/2010/086351    International Application No.:    PCT/EP2010/050969
Publication Date: Fri Aug 06 01:59:59 CEST 2010 International Filing Date: Fri Jan 29 00:59:59 CET 2010
IPC: C07H 17/08
A61K 31/7048
A61P 33/06
Applicants: GLAXO GROUP LIMITED
ALIHODZIC, Sulejman
STARCEVIC, Kristina
Inventors: ALIHODZIC, Sulejman
STARCEVIC, Kristina
Title: 3'-N-SUBSTITUTED 9-DEOXO-9A-METHYL-9A-AZA-HOMOERYTHROMYCIN HAVING ANTIMALARIAL ACTIVITY
Abstract:
The present invention relates to novel 3'-N-substituted 9-deoxo-9a-methyl-9a-aza-9a- homoerythromycin A derivatives having antimalarial activity. More particularly, the invention relates to 3'-N-substituted-9-deoxo-9a-methyl-9a-aza-9a-homoerythromycin A and 3'-N-substituted-3-O-decladinosyl-9-deoxo-9a-methyl-9a-aza-9a-homoerythromycin A derivatives having antimalarial activity, to the intermediates for their preparation, to the methods for their preparation, to their use as therapeutic agents, and to salts thereof having antimalarial activity.