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1. WO2010086349 - ANTI-INFLAMMATORY MACROLIDE

Publication Number WO/2010/086349
Publication Date 05.08.2010
International Application No. PCT/EP2010/050967
International Filing Date 28.01.2010
Chapter 2 Demand Filed 30.11.2010
IPC
C07H 17/08 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
17Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
04Heterocyclic radicals containing only oxygen as ring hetero atoms
08Hetero rings containing eight or more ring members, e.g. erythromycins
A61K 31/7048 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7042Compounds having saccharide radicals and heterocyclic rings
7048having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin
A61P 29/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
CPC
A61K 31/7048
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7042Compounds having saccharide radicals and heterocyclic rings
7048having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin ; digitoxin or digoxin
A61P 1/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
A61P 11/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
A61P 11/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
06Antiasthmatics
A61P 13/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
12of the kidneys
A61P 17/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
06Antipsoriatics
Applicants
  • GLAXO GROUP LIMITED [GB]/[GB] (AllExceptUS)
  • DAY, Caroline, Jane [GB]/[GB] (UsOnly)
  • DOUILLET, Julien, Bruno [FR]/[GB] (UsOnly)
  • FILIC, Darko [HR]/[HR] (UsOnly)
  • KINDON, Leanda, Jane [GB]/[GB] (UsOnly)
  • KRAGOL, Goran [HR]/[HR] (UsOnly)
  • MARUSIC-ISTUK, Zorica [HR]/[HR] (UsOnly)
Inventors
  • DAY, Caroline, Jane
  • DOUILLET, Julien, Bruno
  • FILIC, Darko
  • KINDON, Leanda, Jane
  • KRAGOL, Goran
  • MARUSIC-ISTUK, Zorica
Agents
  • CRAWLEY, Karen
Priority Data
61/148,60930.01.2009US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) ANTI-INFLAMMATORY MACROLIDE
(FR) MACROLIDE ANTI-INFLAMMATOIRE
Abstract
(EN) The compound 3'-N-demethyl-4"-O-(2-diethylaminoethanoyl)-6-O-methyl-9a-aza-9a- homoerythromycin A, having the Formula (I): or a salt thereof, compositions comprising the compound, its use in the treatment of neutrophil dominated inflammatory diseases, and methods for its preparation.
(FR) La présente invention porte sur le composé 3'-N-déméthyl-4''-O-(2-diéthylaminoéthanoyl)-6-O-méthyl-9a-aza-9a-homoérythromycine A, répondant à la formule (I) ou un sel de celui-ci, sur des compositions comprenant le composé, sur ses utilisations pour le traitement de maladies inflammatoires dominées par les neutrophiles et sur ses procédés de préparation.
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