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1. WO2010086197 - LOW MOLECULAR WEIGHT SULPHATED POLYSACCHARIDES AS CANDIDATES FOR ANTI-ANGIOGENIC THERAPY

Publication Number WO/2010/086197
Publication Date 05.08.2010
International Application No. PCT/EP2010/050107
International Filing Date 07.01.2010
IPC
C08B 37/00 2006.01
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
BPOLYSACCHARIDES; DERIVATIVES THEREOF
37Preparation of polysaccharides not provided for in groups C08B1/-C08B35/110; Derivatives thereof
A61K 31/737 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
737Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
CPC
A61P 17/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
A61P 19/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
02for joint disorders, e.g. arthritis, arthrosis
A61P 27/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
27Drugs for disorders of the senses
02Ophthalmic agents
A61P 27/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
27Drugs for disorders of the senses
02Ophthalmic agents
06Antiglaucoma agents or miotics
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 35/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
02specific for leukemia
Applicants
  • THERAPOL [FR]/[FR] (AllExceptUS)
  • DAVID, Laurent [FR]/[FR] (UsOnly)
  • FRANK, Laetitia [FR]/[FR] (UsOnly)
  • SIALI, Rosa [FR]/[FR] (UsOnly)
  • HUET, Jean [FR]/[FR] (UsOnly)
Inventors
  • DAVID, Laurent
  • FRANK, Laetitia
  • SIALI, Rosa
  • HUET, Jean
Agents
  • DE MAREÜIL-VILLETTE, Caroline
Priority Data
PCT/IB2009/05197728.01.2009IB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) LOW MOLECULAR WEIGHT SULPHATED POLYSACCHARIDES AS CANDIDATES FOR ANTI-ANGIOGENIC THERAPY
(FR) POLYSACCHARIDES SULFATÉS DE FAIBLE MASSE MOLÉCULAIRE COMME CANDIDATS POUR UNE THÉRAPIE ANTIANGIOGÉNIQUE
Abstract
(EN)
Low molecular weight sulphated L-fucose polysaccharide fraction having a molecular weight ranging from 11 to 30 kDa when measured with TEST A, a sulphate content ranging from 10 and 50% w/w relative to the total weight of the fraction, a fucosis content ranging from 30 and 70% w/w relative to the total weight of the fraction, and a polydispersity index ranging from 1 and 2, wherein the fraction is obtainable by free radical depolymerisation of a crude fucan of vegetal origin; process for manufacturing same; pharmaceutical composition and medicament containing same and their use for inhibiting neovascularisation.
(FR)
L'invention porte sur une fraction de polysaccharides du L-fucose sulfatés de faible masse moléculaire dont la masse moléculaire est de 11 à 30 kDa lorsqu'elle est mesurée par un TEST A, et dont la teneur en sulfate est de 10 à 50 % p/p par rapport au poids total de la fraction, la teneur en fucose est de 30 à 70 % p/p par rapport au poids total de la fraction et l'indice de polydispersité est de 1 à 2, la fraction pouvant être obtenue par la dépolymérisation radicalaire d'un fucane brut d'origine végétale. L'invention porte également sur un procédé pour sa fabrication, sur une composition pharmaceutique et un médicament contenant ladite composition et sur leur utilisation pour l'inhibition d'une néovascularisation.
Also published as
Latest bibliographic data on file with the International Bureau