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1. (WO2010085682) STABILIZED FC POLYPEPTIDES WITH REDUCED EFFECTOR FUNCTION AND METHODS OF USE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/085682 International Application No.: PCT/US2010/021853
Publication Date: 29.07.2010 International Filing Date: 22.01.2010
IPC:
C12P 21/08 (2006.01) ,C07K 16/00 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
21
Preparation of peptides or proteins
08
Monoclonal antibodies
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
Applicants:
BIOGEN IDEC MA INC. [US/US]; 14 Cambridge Center Cambridge, MA 02142, US (AllExceptUS)
REYES, Christopher, L. [US/US]; US (UsOnly)
CHAN, Eric [US/US]; US (UsOnly)
TAYLOR, Frederick, R. [US/US]; US (UsOnly)
GARBER, Ellen [US/US]; US (UsOnly)
MILLER, Brian, Robert [US/US]; US (UsOnly)
DEMAREST, Stephen [US/US]; US (UsOnly)
GLASER, Scott [US/US]; US (UsOnly)
Inventors:
REYES, Christopher, L.; US
CHAN, Eric; US
TAYLOR, Frederick, R.; US
GARBER, Ellen; US
MILLER, Brian, Robert; US
DEMAREST, Stephen; US
GLASER, Scott; US
Agent:
CLAUSS, Isabell, M.; Lahive & Cockfield, Llp One Post Office Square Boston, MA 02109-2127, US
Priority Data:
61/146,95023.01.2009US
Title (EN) STABILIZED FC POLYPEPTIDES WITH REDUCED EFFECTOR FUNCTION AND METHODS OF USE
(FR) POLYPEPTIDES FC STABILISÉS AVEC UNE FONCTION EFFECTRICE RÉDUITE ET PROCÉDÉS D'UTILISATION
Abstract:
(EN) A method of producing Fc-containing polypeptides, such as antibodies, having stabilized Fc regions is provided, together with stabilized Fc polypeptides produced according to these methods as well as methods of using such antibodies as therapeutics.
(FR) La présente invention concerne un procédé de production de polypeptides contenant Fc, tels que des anticorps, ayant des régions Fc stabilisées. L'invention propose également des polypeptides Fc stabilisés produits selon ces procédés ainsi que des procédés d'utilisation de ces anticorps en tant que produits thérapeutiques.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
NZ594562IL214259EP2389192JP2012515556US20120100140CN102369291
CA2750533MX2011007833BRPI1006998NZ608108AU2010206681IN6281/DELNP/2011