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1. (WO2010085632) VIRTUAL CORE FLOW CYTOMETRY
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/085632 International Application No.: PCT/US2010/021787
Publication Date: 29.07.2010 International Filing Date: 22.01.2010
IPC:
G01N 15/14 (2006.01) ,G01N 33/483 (2006.01) ,G01N 21/53 (2006.01) ,G01N 35/08 (2006.01)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
15
Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
10
Investigating individual particles
14
Electro-optical investigation
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
483
Physical analysis of biological material
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21
Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible, or ultra-violet light
17
Systems in which incident light is modified in accordance with the properties of the material investigated
47
Scattering, i.e. diffuse reflection
49
within a body or fluid
53
within a flowing fluid, e.g. smoke
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
35
Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/-G01N33/148; Handling materials therefor
08
using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis
Applicants:
UNIVERSITY OF WASHINGTON [US/US]; 4311-11th Avenue NE, Suite 500 Seattle, WA 98105-4608, US (AllExceptUS)
SWALWELL, Jarred, E. [US/US]; US (UsOnly)
Inventors:
SWALWELL, Jarred, E.; US
Agent:
DODGE, Ryan, E.; Christensen O'Connor Johnson Kindness PLLC 1420 Fifth Avenue, Suite 2800 Seattle, WA 98101-2347, US
Priority Data:
61/147,03523.01.2009US
61/147,06023.01.2009US
Title (EN) VIRTUAL CORE FLOW CYTOMETRY
(FR) CYTOMÉTRIE DE FLUX À COEUR VIRTUEL
Abstract:
(EN) A sheathless flow cytometry system is disclosed wherein a fluid containing particles of interest, for example cells, flows through a sensing region, and is illuminated in the sensing region with one or more light source. Light resulting from the interaction of the particles with the illumination is received by an objective, and focused toward a field stop having an aperture comprising relatively large end portions and a relatively small center portion. Light deflectors, such as prisms, are disposed over the relatively large end portions of the aperture. The system is arranged such that light from particles in focus in the sensing region is focused on the relatively small center portion of the aperture. Peripheral detectors are positioned to receive light from the light deflectors, and a scatter detector is positioned to receive light passing through the center portion. The detector signals may be used to identify which of the detector signals correspond to particles in focus as they passed through the sensing region.
(FR) La présente invention concerne un système de cytométrie de flux sans gaine dans lequel un fluide contenant des particules d'intérêt, par exemple des cellules, s'écoule à travers une région de détection et est éclairé, dans ladite région de détection, par une ou plusieurs sources de lumière. La lumière résultant de l'interaction entre les particules et l'éclairage est reçue par un objectif et concentrée vers un premier diaphragme de champ comportant une ouverture comprenant des parties terminales relativement grandes et une partie centrale relativement petite. Des déflecteurs de lumière, par exemple des prismes, sont disposés par-dessus les parties terminales relativement grandes de l'ouverture. Le système est disposé de façon à ce que la lumière en provenance des particules convergeant dans la région de détection soit focalisée vers la partie centrale relativement petite de l'ouverture. Des détecteurs périphériques sont positionnés de façon à recevoir la lumière en provenance des déflecteurs de lumière et un détecteur à diffusion est positionné de façon à recevoir la lumière traversant la partie centrale. Les signaux des détecteurs peuvent être utilisés pour identifier le signal des détecteurs qui correspond aux particules focalisées lors de leur passage à travers la région de détection.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
US20120050738